Reproductive failure in common seals feeding on fish from polluted coastal waters

Peter J H Reijnders


The population of common seal Phoca vitulina in the westernmost part of the Wadden Sea, The Netherlands, has collapsed during the past few decades. Between 1950 and 1975 the population dropped from more than 3,000 to less than 500 animals. Comparative studies of common seal populations from different parts of the Wadden Sea reveal that pup production has declined sharply only in the western (Dutch) part. A comparative toxicological study on the levels of heavy metals and organochlorines in tissues of seals from the western and northern parts of the Wadden Sea shows that only the polychlorinated biphenyl (PCB) levels differ significantly. This is predominantly a result of PCB pollution from the river Rhine, which mainly affects the western (Dutch) part. PCBs are thought to be responsible for the low rate of reproduction in Dutch common seals on the basis of epidemiological and experimental data on the ability of PCBs to interfere with mammalian reproduction. Here I report that reproductive failure in common seals from the Dutch Wadden Sea is related to feeding on fish from that polluted area. This is the first demonstration of a causal relationship between naturally occurring levels of pollutants and a physiological response in ...Continue Reading


Jul 15, 1972·British Medical Journal·R FinnV Denye
Nov 1, 1970·Journal of Agricultural and Food Chemistry·J Bitman, H C Cecil
Oct 15, 1962·American Journal of Obstetrics and Gynecology·R H ANDRESEN, C W MONROE


Jul 1, 1997·The Journal of Experimental Zoology·N NishimuraT Iguchi
Apr 1, 1994·Archives of Environmental Contamination and Toxicology·J FalandyszK Skóra
Sep 1, 1993·Archives of Environmental Contamination and Toxicology·E Storr-Hansen, H Spliid
Jul 1, 1995·Archives of Environmental Contamination and Toxicology·C A LakeS S Sadove
Jan 1, 1995·Archives of Environmental Contamination and Toxicology·E Storr-HansenJ P Boon
Jul 1, 1989·Bulletin of Environmental Contamination and Toxicology·T J Peterle, R Bentley
Nov 15, 2008·Environmental Science and Pollution Research International·T Höfer
Feb 9, 2006·Archives of Environmental Contamination and Toxicology·Krishna DasUrsula Siebert
Sep 20, 2005·Archives of Environmental Contamination and Toxicology·Kurunthachalam KannanS Tanabe
Jul 7, 2007·Archives of Environmental Contamination and Toxicology·Patricia A FairGregory D Bossart
Jun 1, 1996·Chemosphere·Bjørn M JenssenS H Lorentsen
Jul 15, 1992·The Science of the Total Environment·W L LockhartD J Thomas
Nov 1, 1993·The Science of the Total Environment·P R BeckerR Zeisler
Sep 16, 1994·The Science of the Total Environment·Ross Norstrom, D C Muir
Sep 16, 1994·The Science of the Total Environment·T J O'Shea, R L Brownell
Jan 27, 1990·Lancet·J D McKinneyJ A McLachlan
Aug 16, 1996·Toxicology·P S RossA D Osterhaus
Jul 1, 1992·Comparative Biochemistry and Physiology. Comparative Physiology·U SchumacherU Welsch
May 1, 1995·Veterinary Microbiology·A D OsterhausT Barrett
Apr 1, 1992·Comparative Biochemistry and Physiology. C, Comparative Pharmacology and Toxicology·V J Smith, P A Johnston
Apr 4, 1994·European Journal of Pharmacology·J P BoonM T Hillebrand
Jun 7, 2002·The Science of the Total Environment·Mark E Hahn
Jun 27, 2003·The Science of the Total Environment·Mace G BarronMargaret M Krahn
Dec 31, 1997·The Science of the Total Environment·P T HarrisonC D Humfrey
Jan 15, 2000·The Science of the Total Environment·K E BerntKit M Kovacs
Jun 11, 2002·Marine Environmental Research·Alex AguilarPeter J H Reijnders
Apr 20, 2004·Environmental Pollution·A J HallT Eybator
Dec 31, 2002·Toxicology·J U SkaareØystein Wiig
Mar 7, 1998·Comparative Biochemistry and Physiology. Part C, Pharmacology, Toxicology & Endocrinology·M A CheneyR S Criddle
Apr 6, 1999·Comparative Biochemistry and Physiology. Part C, Pharmacology, Toxicology & Endocrinology·R Käkelä, H Hyvärinen
Feb 13, 2001·The Journal of Steroid Biochemistry and Molecular Biology·J MatthewsT Zacharewski
Jan 5, 2002·Journal of Molecular Graphics & Modelling·R K DeLisleWilliam J Welsh
Nov 1, 1998·Environmental Toxicology and Pharmacology·H W VallackR D Taalman
Dec 19, 2006·Chemical Research in Toxicology·Ching Y WangWilliam J Welsh
Jun 6, 2008·Journal of Environmental Monitoring : JEM·Ruud J B PetersRob J van Delft
Aug 9, 2002·Journal of Toxicology and Environmental Health. Part a·M P SimmondsG M Troisi
May 31, 2003·Journal of Toxicology and Environmental Health. Part a·Sylvia RubyV Dégas
Jan 9, 2004·Journal of Toxicology and Environmental Health. Part a·Irma C OskamJ U Skaare
Nov 18, 2005·Journal of Toxicology and Environmental Health. Part a·Erik RopstadJ U Skaare
May 27, 2006·Journal of Toxicology and Environmental Health. Part a·Niladri BasuHing Man Chan
May 20, 2005·Journal of Toxicology and Environmental Health. Part a·Jennifer NealeRonald S Tjeerdema
May 20, 2005·Journal of Toxicology and Environmental Health. Part a·Milton LevinS De Guise
Sep 22, 2007·Journal of Toxicology and Environmental Health. Part a·Jennifer NealeRonald S Tjeerdema
Jun 24, 2008·Journal of Toxicology and Environmental Health. Part a·Hans WolkersKit M Kovacs
Mar 11, 2011·Journal of Toxicology and Environmental Health. Part a·Vidar BergErik Ropstad
Jul 2, 2010·Biology Letters·Peter J H ReijndersErik Meesters
Oct 17, 2009·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·A Ross BrownCharles R Tyler
Oct 31, 2008·Environmental Health : a Global Access Science Source·Krishna DasMarie-Claire De Pauw-Gillet
Jun 13, 2002·Environmental Health Perspectives·T Colborn
Jun 4, 2004·Environmental Health Perspectives·Marte BraathenBjørn M Jenssen
Dec 1, 1994·Environmental Health Perspectives·T Colborn
Oct 1, 1996·Environmental Health Perspectives·J García-RodríguezP Lardelli-Claret
Aug 1, 1996·Environmental Health Perspectives·J ToppariN E Skakkebaek
Apr 16, 1998·Environmental Health Perspectives·T M CrispY M Patel
Mar 1, 2009·Interdisciplinary Toxicology·Md Wasim AktarAshim Chowdhury
Jul 22, 2011·International Journal of Environmental Research and Public Health·Wissem MnifBenoit Roig
Dec 3, 2005·Reproduction : the Official Journal of the Society for the Study of Fertility·Paola PocarBernd Fischer
Oct 1, 1996·The Veterinary Quarterly·S Broekhuizen
Oct 1, 1993·Environmental Health Perspectives·T ColbornA M Soto
Apr 1, 1998·Journal of Chromatography. B, Biomedical Sciences and Applications·D L Hayteas, D A Duffield
Feb 22, 2016·Ecotoxicology and Environmental Safety·Xinyi LiYuhui Zhang
Oct 27, 2015·Archives of Environmental Contamination and Toxicology·Liesbeth Weijs, Annalisa Zaccaroni
Aug 21, 2015·Archives of Environmental Contamination and Toxicology·Viola PavlovaJacob Nabe-Nielsen
Jan 25, 2008·Ecological Applications : a Publication of the Ecological Society of America·Tin KlanjscekMichael G Neubert
Jan 25, 2008·Ecological Applications : a Publication of the Ecological Society of America·E E HolmesK Sweeney
Apr 18, 2012·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·Cathy DebierYvan Larondelle
Nov 3, 2015·The Science of the Total Environment·Kimberlee B BeckmenKenneth W Pitcher
Nov 1, 2011·Ecotoxicology and Environmental Safety·Nik VeldhoenCaren C Helbing
Aug 28, 2015·Environmental Toxicology and Chemistry·William R FollandMatthew J Zwiernik
May 19, 2010·The Journal of Urology·Jenny H Yiee, Laurence S Baskin
Feb 23, 2010·Journal of Theoretical Biology·Erik G NoonburgTin Klanjscek
Nov 17, 2009·The Science of the Total Environment·Robert J LetcherGeir W Gabrielsen
Jul 17, 2007·Journal of Comparative Pathology·Ursula SiebertW Baumgärtner
May 26, 2007·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·Ailsa J HallHoward L Rhinehart
Apr 23, 2008·Paediatric and Perinatal Epidemiology·Felice GiordanoIrene Figà-Talamanca
Oct 4, 2007·Journal of Biochemical and Molecular Toxicology·Lotte N MoensW M De Coen
Sep 28, 2010·Integrated Environmental Assessment and Management·Lizzy MosP S Ross
May 30, 2009·Environmental Toxicology·Carlos Alberto Niño-TorresJorge Urbán R
Oct 23, 2014·Biological Reviews of the Cambridge Philosophical Society·Frances Orton, Charles R Tyler
Jan 25, 2005·Marine Pollution Bulletin·Gina M YlitaloFrances M D Gulland
Jan 1, 1989·Acta Paediatrica Scandinavica. Supplement·J G Koppe
Jun 6, 2006·Environment International·Mehmet CoelhanHulusi Barlas
Oct 26, 2005·Ecotoxicology and Environmental Safety·Sultana RaziaTadashi Oishi
Dec 13, 2000·International Journal of Occupational and Environmental Health·J Thornton
May 31, 2014·The Science of the Total Environment·Susan D ShawAdrian Covaci
Jul 6, 2013·The Science of the Total Environment·Paulo R DornelesKrishna Das
Apr 20, 2004·Environmental Pollution·K C Jones, P de Voogt
Aug 30, 2006·Environmental Pollution·Dongli WangQing X Li
Jan 15, 2004·Environmental Pollution·Asunción BorrellJette Jensen
Dec 20, 2005·Environmental Pollution·Mayuko OkaNobuyuki Miyazaki
Dec 15, 2006·Environmental Research·Bruce ThompsonKaren Taberski
Jan 1, 1993·Environmental Pollution·G Wang-AndersenE Steinnes
Apr 25, 2007·Environmental Research·J A DavisL J McKee
Jan 1, 1988·Environmental Pollution·S Tanabe
May 14, 2011·Marine Pollution Bulletin·Thierry JauniauxFreddy Coignoul
Apr 27, 2016·Marine Pollution Bulletin·Paula Méndez-FernandezRosalinda C Montone
Oct 4, 2016·Journal of Zoo and Wildlife Medicine : Official Publication of the American Association of Zoo Veterinarians·Kendra L BauerPamela Tuomi
May 23, 2006·Ecological Applications : a Publication of the Ecological Society of America·Myra FinkelsteinDonald R Smith
Dec 17, 2010·Veterinary Pathology·Gregory D Bossart
Jan 1, 1997·Biomarkers : Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals· M Cristina Fossi And Letizia Marsili
Jul 28, 1988·Nature·A D Osterhaus
Aug 12, 2005·American Journal of Epidemiology·Dionne C Gesink LawMatthew P Longnecker
Nov 10, 2006·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Caroline C Smith, Hugh S Taylor
Feb 29, 2020·Archives of Environmental Contamination and Toxicology·G M TroisiM Nyman
Jan 25, 2002·Annals of the New York Academy of Sciences·K A BoisenN E Skakkebaek
May 14, 2011·Public Health Reports·John S Reif
Oct 18, 2019·International Journal of Biological Macromolecules·Sana SharifianSeema Patel
Nov 25, 2019·Marine Pollution Bulletin·Alexey M Trukhin, Margarita D Boyarova
Jun 29, 1996·The Veterinary Record·H M RossG Foster
Dec 29, 2020·Journal of Toxicology and Environmental Health. Part a·Patricia A FairNatasha D White
Sep 15, 2009·Environmental Science & Technology·Ailsa J HallBernie J McConnell
Apr 26, 2021·Chemosphere·Odei Garcia-GarinAsunción Borrell

Related Concepts

Animal Feed (Substance)
Estradiol, (16 alpha,17 beta)-Isomer
Progesterone, (9 beta,10 alpha)-Isomer
Water Pollution, Chemical

Trending Feeds


Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Lipidomics & Rhinovirus Infection

Lipidomics can be used to examine the lipid species involved with pathogenic conditions, such as viral associated inflammation. Discovered the latest research on Lipidomics & Rhinovirus Infection.

Alzheimer's Disease: MS4A

Variants within the membrane-spanning 4-domains subfamily A (MS4A) gene cluster have recently been implicated in Alzheimer's disease in genome-wide association studies. Here is the latest research on Alzheimer's disease and MS4A.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Torsion Dystonia

Torsion dystonia is a movement disorder characterized by loss of control of voluntary movements appearing as sustained muscle contractions and/or abnormal postures. Here is the latest research.

Generating Insulin-Secreting Cells

Reprogramming cells or using induced pluripotent stem cells to generate insulin-secreting cells has significant therapeutic implications for diabetics. Here is the latest research on generation of insulin-secreting cells.

Central Pontine Myelinolysis

Central Pontine Myelinolysis is a neurologic disorder caused most frequently by rapid correction of hyponatremia and is characterized by demyelination that affects the central portion of the base of the pons. Here is the latest research on this disease.

Epigenome Editing

Epigenome editing is the directed modification of epigenetic marks on chromatin at specified loci. This tool has many applications in research as well as in the clinic. Find the latest research on epigenome editing here.