Abstract
The changes of reproductive functions, fertility and genetic risks of ageing females have been investigated relatively intensively. The state of knowledge about endocrine and reproductive changes in ageing men as well as possible age-related paternal genetic risks lags far behind. In general serum testosterone levels decrease with increasing age. In ageing men testis morphology and semen production can be absolutely normal. However, in some testes degenerative forms of germ cells can be observed. Fertility may be maintained up to a very high age. The genetic quality of sperm produced by older men may be reduced for several reasons, among which age-related increases in germ cell mutations, impairment of DNA-repair mechanisms and apoptotic processes are the most likely. The incidence of several autosomal dominant diseases, such as achondroplasia, polyposis coli, Marfan syndrome, Apert syndrome or basal cell naevi is associated with advanced paternal age, whereas there is no clear evidence for a paternal effect on structural or numeric chromosome anomalies. Hence even if offspring of older men have a slightly increased incidence of certain genetic diseases, the individual risk of such a new disease must be considered as extremely ...Continue Reading
Citations
Oct 1, 2009·Journal of Assisted Reproduction and Genetics·M J Trujillo-TiebasC Ayuso
Jun 21, 2006·Maternal and Child Health Journal·Stuart K Shapira, Siobhan Dolan
Jun 13, 2003·Fertility and Sterility·Mohamed A M Hassan, Stephen R Killick
Apr 23, 2002·Andrologia·A JungW-B Schill
Jan 31, 2002·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Alvin M Matsumoto
Jul 3, 2002·Human Reproduction·C M LuetjensE Nieschlag
Oct 9, 2012·Human Reproduction·Thomas E SchmidAndrew J Wyrobek
Feb 16, 2010·Schizophrenia Research·Mark G A OplerDolores Malaspina
Jan 9, 2010·Annals of Epidemiology·Ridgely Fisk GreenUNKNOWN National Birth Defects Prevention Study
Oct 24, 2007·Joint, Bone, Spine : Revue Du Rhumatisme·Pascal RichetteChantal Stheneur
Apr 17, 2007·Fertility and Sterility·Eddie D SloterAndrew J Wyrobek
Jan 9, 2008·Journal of Evolutionary Biology·M PetersL W Simmons
Apr 7, 2004·Fertility and Sterility·Eddie SloterAndrew J Wyrobek
Apr 18, 2006·Fertility and Sterility·Elise de La RochebrochardUNKNOWN French National IVF Registry (FIVNAT) Association
Mar 18, 2008·Urology·Marcello CocuzzaJorge Hallak
Oct 18, 2007·Urologia Internationalis·Sam SiddighiPhilip J Chan
Jan 8, 2011·Cytogenetic and Genome Research·K G L Fonseka, D K Griffin
Oct 17, 2008·Biology of Reproduction·Silvia García-PalomaresJuan J Tarín
Oct 17, 2008·Biology of Reproduction·Silvia García-PalomaresJuan J Tarín
Feb 28, 2013·Nature Reviews. Urology·Catriona Paul, Bernard Robaire
Sep 21, 2007·Ophthalmic Plastic and Reconstructive Surgery·Gareth T HigginsGerard O'Connor
Jan 11, 2018·Clinical Obstetrics and Gynecology·Jessica C Arluck, Allison C Mayhew
Jul 16, 2004·CNS Spectrums·Dolores MalaspinaShmuel Fennig
Jun 3, 2015·Electrophoresis·Xin LiuWen-Juan Wang