Reproductive hormones in relation to polycyclic aromatic hydrocarbon (PAH) metabolites among non-occupational exposure of males

The Science of the Total Environment
Yan HanXinru Wang

Abstract

A limited number of studies have suggested that exposure to PAHs may affect reproductive hormones. Subjects (n=642) in this study were from the affiliated hospitals of Nanjing Medical University. Individual exposures to PAHs were measured as spot urinary concentrations of four PAH metabolites, including 1-naphthol (1-N), 2-naphthol (2-N), 2-hydroxyfluorene (2-OF) and 1-hydroxypyrene (1-OP), which were adjusted by urinary creatinine (CR). Blood samples were collected to measure serum levels of reproductive hormones, including follicle-stimulating hormone (FSH), luteotrophic hormone (LH), estradiol (E2), testosterone (T) and prolactin (PRL). All of the subjects had detectable levels of the four metabolites of PAHs in their urine samples. The median concentrations of 1-N, 2-N, 2-OF and 1-OP were 2.440, 4.176, 2.843 and 1.148 microg/g of CR. There were significant P-values between increased CR-adjusted 1-N tertiles and E2 concentration, 2-OF tertiles and LH, FSH level, 1-OP and E2 level. The multivariate linear regression results also showed significant correlation between the levels of serum LH and 1-OP (the adjusting P-value was 0.048), but no correlations were found between other hormones and the level of PAH metabolites. These ...Continue Reading

References

Jan 1, 1995·Chemical Research in Toxicology·E BauerF P Guengerich
Oct 1, 1993·Environmental Health Perspectives·T ColbornA M Soto
Jun 1, 1993·Journal of Occupational Medicine. : Official Publication of the Industrial Medical Association·S M SchraderS D Simon
Oct 1, 1995·Environmental Health Perspectives·T Colborn
Apr 27, 2001·Annals of Surgery·K Z'graggenC Fernández-Del Castillo
Sep 28, 2001·Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP·M Evanson, G J Van Der Kraak
Aug 9, 2002·Journal of Toxicology and Environmental Health. Part a·Michèle BouchardClaude Viau
Mar 19, 2004·The Journal of Biological Chemistry·Daniel W NebertFrank J Gonzalez
Aug 24, 2004·International Archives of Occupational and Environmental Health·Wenlin HuangEric J Sampson
Sep 2, 2004·Journal of Exposure Analysis and Environmental Epidemiology·John D MeekerRuss Hauser
Oct 30, 2004·International Journal of Toxicology·Aramandla RameshEric H Weyand
Dec 14, 2004·Human Reproduction·Susan M DutyRuss Hauser
Jun 23, 2006·Archives of Environmental Health·Marilie D GammonRegina M Santella
Dec 16, 2006·Environmental Monitoring and Assessment·Wenjie ZhangGaiying Ren
Jul 7, 2007·The Journal of Reproduction and Development·Hiromi IzawaMasaru Sagai

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Citations

Mar 27, 2013·Environmental Science and Pollution Research International·Andrew Ball, Adam Truskewycz
Apr 1, 2016·Environmental Pollution·Joanna JurewiczWojciech Hanke
Mar 17, 2015·European Journal of Public Health·Chisato NagataKeigo Yasuda
Sep 4, 2012·The Science of the Total Environment·Gustavo Faibischew PradoUbiratan de Paula Santos
Jun 22, 2011·The Science of the Total Environment·Sepideh Arbabi BidgoliMansour Djamali Zavarhei
Jul 30, 2017·Environmental Health : a Global Access Science Source·Julie CarréRoger Léandri
Dec 6, 2020·International Journal of Molecular Sciences·Elizabeth C Plunk, Sean M Richards
Jan 31, 2020·Environmental Research·Ching-Chun HuangYue Leon Guo
Nov 3, 2021·Journal of Applied Toxicology : JAT·Yukio KawashimaTaisen Iguchi

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