Reproductive immunology in viviparous mammals: evolutionary paradox of interactions among immune mechanisms and autologous or allogeneic gametes and semiallogeneic foetuses.

The Veterinary Quarterly
M SamardžijaI Valpotić

Abstract

Literally, reproductive immunology was born in bovine on-farm reproduction where seminal experiments intended for developing methods for embryo transfer in cattle were performed. Actually, these experiments led to two of major concepts and fundamental principles of reproductive immunology using the bovine species as a model for biomedical research, namely the concept of acquired immunological tolerance and the paradox of the semiallogeneic bovine foetus whereby such organism can develop within an immunologically competent host. Peter Medawar, a scientist who together with Frank Macfarlande Burnet shared the 1960 Nobel Prize in physiology or medicine for discovery of acquired immunological tolerance, while studying dizygotic cattle twins, thereby giving birth to reproductive immunology. Also, these findings significantly influenced development of organ transplants and showed that using farm animals as models for studying transplantation immunology had general relevance for mammalian biology and health including those of humans. However, the interest for further research of the fascinating maternal immune influences on pregnancy and perinatal outcomes and of the prevention and treatment of immunologically mediated reproductive di...Continue Reading

References

May 1, 1979·Tissue Antigens·J Caldwell
Feb 27, 1975·Nature·D P Stites, R P Erickson
Jan 1, 1976·Scandinavian Journal of Immunology·C PrakashG Möller
Jan 1, 1978·Animal Blood Groups and Biochemical Genetics·P Millot
Sep 1, 1992·American Journal of Reproductive Immunology : AJRI·G SkibinskiK James
Aug 1, 1992·Journal of Reproductive Immunology·G SkibinskiK James
Jul 1, 1990·American Journal of Obstetrics and Gynecology·H N HoT Y Lee
Apr 13, 1990·Science·S KovatsR DeMars
Jan 1, 1989·Current Opinion in Immunology·R RaghupathyS K Gupta
Sep 1, 1985·Journal of Dairy Science·H A FahmiB E Seguin
Jun 1, 1988·American Journal of Reproductive Immunology and Microbiology : AJRIM·S S Witkin
Sep 1, 1988·Tissue Antigens·M GerencerA Kastelan
Apr 1, 1987·Journal of in Vitro Fertilization and Embryo Transfer : IVF·R H Foote
Aug 1, 1986·Mayo Clinic Proceedings·J E LewisS B Moore
Dec 1, 1985·Journal of Dairy Science·H A Fahmi, A G Hunter
Nov 1, 1968·Journal of Reproduction and Fertility·M H Johnson, B P Setchell
Feb 9, 1968·Science·D B Amos
Aug 1, 1970·Transplantation·M VaimanP Nizza
Apr 7, 1971·Nature: New Biology·J J Van RoodW Van Vreeswijk
Jun 1, 1967·Journal of Reproduction and Fertility·A C Menge
Jan 1, 1984·Perspectives in Biology and Medicine·R E Billingham, A E Beer
Feb 1, 1995·Veterinary Immunology and Immunopathology·M LazarevicK James
May 1, 1994·Fertility and Sterility·P B Marshburn, W H Kutteh
May 10, 1994·Proceedings of the National Academy of Sciences of the United States of America·M KirszenbaumE Carosella
Feb 1, 1993·Current Opinion in Immunology·D E Geraghty
Jan 9, 1996·Proceedings of the National Academy of Sciences of the United States of America·K ToshitaniW F Bodmer
Nov 1, 1996·Veterinary Immunology and Immunopathology·B Charley
Jan 1, 1997·Current Topics in Microbiology and Immunology·C Ober, K van der Ven
Oct 3, 1953·Nature·R E BILLINGHAMP B MEDAWAR

❮ Previous
Next ❯

Methods Mentioned

BETA
RSA
ELISA
gel-filtration
column chromatography

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Human Reproduction Update
A L Veenstra van NieuwenhovenM M Faas
American Journal of Reproductive Immunology : AJRI
Manish Garg
© 2021 Meta ULC. All rights reserved