Reproductive, menstrual, and other hormone-related factors and risk of renal cell cancer

International Journal of Cancer. Journal International Du Cancer
Antonella ZucchettoSilvia Franceschi

Abstract

A role of hormone-related factors in renal cell cancer (RCC) etiology has been hypothesized, but the epidemiological evidence is inconsistent. The present study aimed at evaluating the effect of reproductive, menstrual and other gender-specific variables on RCC risk among women. This study is part of a larger hospital-based, case-control study on RCC risk, conducted in northern, central and southern Italy. Cases were 273 women, below age 80, with histologically confirmed, incident RCC. Controls were 546 women hospitalized for acute, nonneoplastic conditions, frequency-matched to cases by age and center. Odds ratios (OR) and 95% confidence intervals (CI) were computed using multiple logistic regression models. RCC risk was inversely related to age at first birth (OR = 0.7, 95% CI 0.5-1.0, for >/= 25 years vs. <25 years). Hysterectomy was found to double RCC risk (OR = 2.3, 95% CI 1.3-4.2). A negative association of borderline-statistical significance emerged for age at menarche, whereas, no associations were found between RCC risk and parity, menopausal status, age at menopause and use of hormone replacement therapy or oral contraceptives. Our findings give support to a role of hysterectomy in increasing RCC risk without corrobo...Continue Reading

References

Oct 31, 1992·International Journal of Cancer. Journal International Du Cancer·J K McLaughlinJ F Fraumeni
Apr 10, 1995·International Journal of Cancer. Journal International Du Cancer·P LindbladJ S Mandel
Jan 27, 1995·International Journal of Cancer. Journal International Du Cancer·W H ChowJ F Fraumeni
Jan 2, 1994·International Journal of Cancer. Journal International Du Cancer·A MellemgaardJ H Olsen
Mar 1, 1993·Cancer Causes & Control : CCC·N KreigerG A Darlington
Feb 1, 1993·Urology·G ConcolinoF Di Silverio
Sep 16, 1998·American Journal of Epidemiology·J BenichouJ F Fraumeni
Oct 11, 2001·British Journal of Cancer·A BergströmA Wolk
May 3, 2002·British Journal of Cancer·Mats LambeC-c Hsieh
May 22, 2002·Cancer Causes & Control : CCC·Manuela Gago-DominguezMimi C Yu
Apr 22, 2003·International Journal of Cancer. Journal International Du Cancer·Esteve FernandezCarlo La Vecchia
May 29, 2003·Molecular and Cellular Endocrinology·Yuichiro TanakaRajvir Dahiya
Aug 3, 2004·Nature Reviews. Cancer·Eugenia E Calle, Rudolf Kaaks
Nov 4, 2004·International Journal of Cancer. Journal International Du Cancer·Jay D HuntPaul Brennan
Jan 31, 2006·European Urology·Antonio Lopez-BeltranZiya Kirkali
Dec 13, 2006·Annals of Oncology : Official Journal of the European Society for Medical Oncology·A ZucchettoC La Vecchia
Feb 22, 2007·British Journal of Cancer·G C KabatT E Rohan
Jun 27, 2007·American Journal of Epidemiology·Luigino Dal MasoSilvia Franceschi
Sep 8, 2007·Maturitas·Jennifer C MolokwuAaron R Folsom

❮ Previous
Next ❯

Citations

Mar 31, 2009·American Journal of Epidemiology·Jung Eun LeeEunyoung Cho
Apr 14, 2011·BMC Cancer·Loren LipworthJoseph K McLaughlin
Jun 12, 2013·European Journal of Public Health·Hui-Fen ChiuChun-Yuh Yang
Jan 7, 2009·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Veronica Wendy SetiawanBrian E Henderson
Apr 30, 2013·American Journal of Epidemiology·Sara KaramiMark P Purdue
Jul 3, 2013·International Journal of Cancer. Journal International Du Cancer·Sara KaramiMark P Purdue
Jul 14, 2016·Journal of Advanced Research·Hussein KhaledNoha Rashad
Oct 6, 2015·Nature Reviews. Urology·Ilaria LuccaShahrokh F Shariat
Jan 9, 2019·Pathology Oncology Research : POR·Tamás DeliAttila Jakab
Jul 17, 2020·Cancer Control : Journal of the Moffitt Cancer Center·Xiaojun ZhangAnguo Wang
May 14, 2020·International Journal of Molecular Sciences·Mariangela ManciniGiovannella Baggio
Apr 2, 2016·International Journal of Oncology·Anna M CzarneckaCezary Szczylik
Oct 11, 2013·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Hong-Bo GuanTing-Ting Gong
Jun 26, 2020·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Rita PeilaThomas E Rohan
Dec 19, 2020·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Juhua LuoMichael Hendryx
Aug 8, 2021·Cancers·Zahra PasdarSohinee Bhattacharya

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology
Veronica Wendy SetiawanBrian E Henderson
International Journal of Cancer. Journal International Du Cancer
W H ChowJoseph F Fraumeni
© 2022 Meta ULC. All rights reserved