Reproductive outcome is optimized by genomic embryo screening, vitrification, and subsequent transfer into a prepared synchronous endometrium

Journal of Assisted Reproduction and Genetics
Jorge Rodriguez-PurataTanmoy Mukherjee

Abstract

The aim of this study is to compare implantation and live birth rates (LBR) between fresh euploid embryo transfers versus cryo-all cycles with a subsequent embryo transfer into a prepared endometrium. This is a retrospective cohort study. Patients who underwent an IVF cycle with PGS with trophectoderm biopsy from January 2011 to July 2015 were included. Patients were divided into three groups: "Fresh Only," "Frozen Embryo Transfer ('FET) Only," and "Fresh ET then FET." For "Fresh Only" group (n = 345), PGS results were received within 24 h. For "FET Only" group (n = 514), results were expected after 24 h, and embryos were cryopreserved after biopsy; only FET was performed in this group (no fresh transfer). For "FET with a previous fresh ET" (n = 139) group, patients underwent a fresh ET with a subsequent FET, in which the same cohort of embryos was utilized. The main outcome measures were pregnancy rate (PR), clinical PR, implantation rate (IR), LBR, and early pregnancy loss rate. IRs were statistically higher in the "FET Only" group when compared to the "Fresh Only" group (59.5 vs. 50.6%, p < 0.01) and the "FET with a previous fresh ET" (59.5 vs. 50.6%, p < 0.05). LBR was statistically significant in the "FET Only" group when ...Continue Reading

References

Jan 1, 1991·Fertility and Sterility·D NavotZ Rosenwaks
Jun 11, 1999·The New England Journal of Medicine·A J WilcoxC R Weinberg
Jan 5, 2002·Human Reproduction·K ThomasD I Lewis-Jones
Jun 27, 2003·Trends in Endocrinology and Metabolism : TEM·Bart C J M Fauser, Paul Devroey
Jul 10, 2003·Fertility and Sterility·Rebecca L DubowyHarvey J Kliman
Nov 11, 2003·Fertility and Sterility·UNKNOWN Practice Committe of the American Society for Reproductive Medicine
Apr 12, 2005·Fertility and Sterility·Ole B ChristiansenKatrin van der Ven
Mar 20, 2009·Fertility and Sterility·Bruce S ShapiroShyni Thomas
Jan 26, 2010·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Georg GriesingerAskan Schultze-Mosgau
Jul 14, 2010·Fertility and Sterility·Patricia Díaz-GimenoCarlos Simón
Jul 29, 2010·Fertility and Sterility·Suleena Kansal KalraKurt T Barnhart
Dec 14, 2011·Journal of Assisted Reproduction and Genetics·Eun Mi ChangWoo Sik Lee
Dec 24, 2011·Fertility and Sterility·UNKNOWN Practice Committee of American Society for Reproductive Medicine
Feb 22, 2012·Gynécologie, obstétrique & fertilité·D El BahjaJ-P Ragage
Mar 2, 2012·Reproductive Biomedicine Online·M Al-AzemiH M Fatemi
Jan 15, 2013·Fertility and Sterility·Tamara Garrido-GómezCarlos Simón
Jun 22, 2013·Current Opinion in Obstetrics & Gynecology·Yvonne E M Koot, Nick S Macklon
Aug 13, 2013·Reproductive Biomedicine Online·H M Fatemi, B Popovic-Todorovic
Feb 5, 2014·Obstetrics and Gynecology Clinics of North America·Sotirios H Saravelos, Lesley Regan
Mar 19, 2014·American Journal of Reproductive Immunology : AJRI·Carolina von GrothusenParameswaran G Lalitkumar
Jun 25, 2014·Seminars in Reproductive Medicine·David BlesaCarlos Simón
Nov 28, 2014·Journal of Assisted Reproduction and Genetics·Matheus Roque

❮ Previous
Next ❯

Citations

May 15, 2016·Reproductive Biomedicine Online·Bruce S ShapiroCynthia Hudson
Nov 7, 2016·Journal of Assisted Reproduction and Genetics·Matheus RoqueSelmo Geber
Jan 29, 2019·Reproduction : the Official Journal of the Society for the Study of Fertility·Jorge Rodriguez-Purata, Francisca Martinez
May 14, 2019·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Francisca MartínezNikolaos Polyzos
Apr 25, 2020·Human Reproduction·Rachel TheobaldJoyce Harper
Jun 16, 2017·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Elena M FedorovaAlla S Kalugina
Jan 4, 2018·Journal of Assisted Reproduction and Genetics·Leah KayeClaudio Benadiva
Jul 21, 2020·Reproductive Medicine and Biology·Naoki Aoyama, Keiichi Kato
Feb 8, 2019·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Jorge Rodriguez-PurataBuenaventura Coroleu
Nov 24, 2018·Obstetrical & Gynecological Survey·Michelle A WoodSteven R Lindheim
Dec 29, 2020·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·Margeaux OlivaAlan B Copperman
Jan 2, 2021·Reproductive Biomedicine Online·Mathilde BourdonPietro Santulli
Apr 28, 2021·Journal of Assisted Reproduction and Genetics·Kaitlyn RocheJoyce Harper
Jul 27, 2021·Journal of Assisted Reproduction and Genetics·Margeaux OlivaLucky Sekhon

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.