Reproductive outcome of patients undergoing in vitro fertilisation treatment and diagnosed with bacterial vaginosis or abnormal vaginal microbiota: a systematic PRISMA review and meta-analysis

BJOG : an International Journal of Obstetrics and Gynaecology
T HaahrP Humaidan

Abstract

Despite recent efforts, the risks associated with bacterial vaginosis (BV) or abnormal vaginal microbiota in IVF patients are not well-established. We aimed to evaluate the risks associated with BV in IVF patients using meta-analysis. Following preliminary searches to find relevant keywords and MeSH terms, a systematic search was performed in PubMed (MEDLINE) in September 2017. The population was infertile women attending IVF treatment. The exposure was BV or abnormal vaginal microbiota. Outcomes included live birth rate, early spontaneous abortion rate and clinical pregnancy rate. Data were collected for each study and for each outcome using a summary of findings table. If appropriate, data were quantitatively assessed using meta-analysis, sensitivity analysis, funnel plots and GRADE evidence assessment were performed for the above-mentioned outcomes. A total of 12 studies were eligible, comprising a total of 2980 patients. The prevalence of BV was 16% (95% CI 15-18%) in the general study population and tubal factor infertility was highly prevalent in patients diagnosed with BV compared with normal vaginal microbiota patients (P = 0.001). Despite a significant association with early spontaneous abortion [relative risk (RR) 1.6...Continue Reading

References

Jan 1, 1983·British Journal of Hospital Medicine·S G Dawson, J R Harris
Jul 4, 2003·Infectious Diseases in Obstetrics and Gynecology·Linda O EckertDavid A Eschenbach
Mar 18, 2006·BMC Infectious Diseases·Ellen De BackerMario Vaneechoutte
Nov 17, 2007·American Journal of Obstetrics and Gynecology·Alexander SwidsinskiHans Verstraelen
May 1, 2008·Indian Journal of Medical Microbiology·P Nagaraja
Jul 22, 2009·PLoS Medicine·David MoherUNKNOWN PRISMA Group
Jun 11, 2010·Proceedings of the National Academy of Sciences of the United States of America·Jacques RavelLarry J Forney
Sep 4, 2010·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·J-P MenardF Bretelle
Nov 8, 2012·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·J Mangot-BertrandB Courbiere
Jan 16, 2013·PloS One·Alexander SwidsinskiZaher Halwani
Nov 8, 2013·Journal of Clinical Microbiology·Raluca DatcuJørgen Skov Jensen
May 23, 2014·Science Translational Medicine·Kjersti AagaardJames Versalovic
Dec 20, 2014·American Journal of Obstetrics and Gynecology·Caroline M MitchellDavid Eschenbach
Feb 13, 2016·Clinical Microbiology Reviews·Andrew B OnderdonkRaina N Fichorova
Oct 21, 2016·American Journal of Obstetrics and Gynecology·Inmaculada MorenoCarlos Simon
Jul 26, 2017·Human Fertility : Journal of the British Fertility Society·Ashraf MoiniAzam Sanati
Aug 30, 2017·Proceedings of the National Academy of Sciences of the United States of America·Benjamin J CallahanDavid A Relman
Mar 1, 2016·Turkish Journal of Obstetrics and Gynecology·Özlem EldivanÜmit Göktolga

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Citations

Aug 23, 2018·American Journal of Reproductive Immunology : AJRI·Timothy Bracewell-MilnesMeen-Yau Thum
Oct 2, 2019·BJOG : an International Journal of Obstetrics and Gynaecology·M Al-MemarD A MacIntyre
Aug 26, 2019·Journal of Assisted Reproduction and Genetics·Andrea BernabeuRafael Bernabeu
Mar 17, 2020·Current Opinion in Obstetrics & Gynecology·Sam Schoenmakers, Joop Laven
Aug 10, 2019·BJOG : an International Journal of Obstetrics and Gynaecology·B P JonesJ R Smith
Sep 27, 2020·Reproductive Biomedicine Online·Malene Hviid SaxtorphNick Macklon
Mar 17, 2020·Journal of Gynecology Obstetrics and Human Reproduction·M HamdounO Bahri
Dec 12, 2020·Journal of Gynecology Obstetrics and Human Reproduction·O TsonisM Paschopoulos
Oct 23, 2020·American Journal of Obstetrics and Gynecology·Jacques RavelCarlos Simón
Aug 8, 2020·Gynécologie, Obstétrique, Fertilité & Sénologie·C MauriesS Hamamah
Mar 7, 2021·Life·Alessandra CosciaDiego Giampietro Peroni
Oct 15, 2020·Viruses·Rasmus Riemer JakobsenDennis Sandris Nielsen
Apr 6, 2021·Current Infectious Disease Reports·Christina A Muzny, Jane R Schwebke
Apr 27, 2021·Current Opinion in Obstetrics & Gynecology·Lidia Lorite AguileraIgnacio Cristóbal Quevedo
Jun 5, 2021·Journal of Gynecology Obstetrics and Human Reproduction·Chuanfeng DingQian Zhou
Jun 11, 2021·Journal of Assisted Reproduction and Genetics·Paula Punzón-Jiménez, Elena Labarta
May 31, 2021·BJOG : an International Journal of Obstetrics and Gynaecology·A KaraerN Tecellioğlu
Jul 17, 2021·Human Reproduction·Holly Michelle CroweElizabeth Elliott Hatch
Jul 15, 2021·BJOG : an International Journal of Obstetrics and Gynaecology·Xiang HongXu Ma
Aug 17, 2021·Bioscience Reports·Karen GrewalPhillip R Bennett
Sep 10, 2021·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·Thor HaahrJakob Stokholm

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