Reproductive outcomes of maternal contamination with cyclodiene insecticides, hexachlorobenzene and beta-benzene hexachloride

The Science of the Total Environment
Narges Khanjani, Malcolm Ross Sim

Abstract

The effects of organochlorines on human reproduction have been recently under scrutiny. Some negative effects on animal reproduction have been reported. In this study we aimed to evaluate the effect of maternal contamination with a certain group of organochlorines, which are cyclodienes, HCB (hexachlorobenzene) and beta-BHC (beta-hexachlorocyclohexane) on human reproduction. Breast milk samples from 815 eligible Victorian mothers were used for measuring maternal contamination and the reproductive outcomes such as birth weight, head circumference and prematurity were taken from health files. Our study did not show any significant negative effect on outcomes such as birth weight, small for gestation age, previous miscarriage or still birth, head circumference or sex ratio. An inconsistent increase across oxychlordane exposure levels for prematurity was found. We also found an inverse association between the highest levels of HCB and oxychlordane with previous miscarriage or still birth; but this was based on small numbers and may be explained by loss of contaminants through the aborted fetus. These results suggest that the declining contamination levels of these chemicals do not impose a threat to human reproduction.

References

Jan 1, 1977·Archives of Environmental Contamination and Toxicology·D L GrantG V Hatina
May 13, 1998·Archives of Environmental Health·M SimG Roberts
Feb 22, 2000·The Science of the Total Environment·P Bjerregaard, J C Hansen
Aug 3, 2001·Pediatrics·M S KramerUNKNOWN Fetal/Infant Health Study Group of the Canadian Perinatal Surveillance System
Jun 6, 2002·Human & Experimental Toxicology·M K J Siddiqui Chandrawati
Feb 27, 2003·Annals of Epidemiology·Beth C GladenRuth E Little
Jan 31, 2004·American Journal of Reproductive Immunology : AJRI·Mayumi Sugiura-OgasawaraKaoru Suzumori

❮ Previous
Next ❯

Citations

Sep 15, 2009·Environmental Health Perspectives·Brenda EskenaziDarwin Stapleton
Jun 14, 2013·International Journal of Endocrinology·Ewa L Gregoraszczuk, Anna Ptak
Mar 28, 2008·Journal of Toxicology and Environmental Health. Part B, Critical Reviews·Mandy WeselakDaniel Krewski
Dec 15, 2007·Reviews on Environmental Health·Lamar ReedPaul B Tchounwou
May 13, 2008·Journal of Toxicology and Environmental Health. Part B, Critical Reviews·Donald T WigleDaniel Krewski
Jan 1, 2011·Emerging Health Threats Journal·Metrecia L TerrellMichele Marcus
Jun 15, 2013·Journal de gynécologie, obstétrique et biologie de la reproduction·R Slama, S Cordier
Jan 22, 2008·Environment International·Mar Alvarez-PedrerolJordi Sunyer
Aug 27, 2013·The Science of the Total Environment·Mikel BasterrecheaUNKNOWN INMA project
Jan 18, 2015·Applied Biochemistry and Biotechnology·Neelam Verma, Atul Bhardwaj
Jan 17, 2017·Environment International·Tania Fernández-CruzJesús Simal-Gándara
Apr 29, 2015·Environmental Science and Pollution Research International·Johan FångÅke Bergman
Jun 15, 2006·Journal of Exposure Science & Environmental Epidemiology·Narges Khanjani, Malcolm Ross Sim
Jan 1, 2008·Biomarker Insights·Francesco MassartGiuseppe Saggese
Feb 8, 2019·Journal of Environmental Health Science & Engineering·Narges KhanjaniEffat Ahmadi Mousavi
Jun 15, 2011·Pediatrics·Maria-Jose Lopez-EspinosaFerran Ballester

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.