Reproductive period, endogenous estrogen exposure and dementia incidence among women in Latin America and China; A 10/66 population-based cohort study

PloS One
Martin J PrinceAdolfo Valhuerdi

Abstract

Exposure to endogenous estrogen may protect against dementia, but evidence remains equivocal. Such effects may be assessed more precisely in settings where exogenous estrogen administration is rare. We aimed to determine whether reproductive period (menarche to menopause), and other indicators of endogenous estrogen exposure are inversely associated with dementia incidence. Population-based cohort studies of women aged 65 years and over in urban sites in Cuba, Dominican Republic, Puerto Rico and Venezuela, and rural and urban sites in Peru, Mexico and China. Sociodemographic and risk factor questionnaires were administered to all participants, including ages at menarche, birth of first child, and menopause, and parity, with ascertainment of incident 10/66 dementia, and mortality, three to five years later. 9,428 women participated at baseline, with 72-98% responding by site. The 'at risk' cohort comprised 8,466 dementia-free women. Mean age varied from 72.0 to 75.4 years, lower in rural than urban sites and in China than in Latin America. Mean parity was 4.1 (2.4-7.2 by site), generally higher in rural than urban sites. 6,854 women with baseline reproductive period data were followed up for 26,463 person years. There were 692 c...Continue Reading

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Citations

Oct 12, 2019·The Journals of Gerontology. Series B, Psychological Sciences and Social Sciences·Joseph L SaenzEileen M Crimmins
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Oct 7, 2021·The Journals of Gerontology. Series B, Psychological Sciences and Social Sciences·Alison Gemmill, Jordan Weiss

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Methods Mentioned

BETA
hormone replacement therapy

Software Mentioned

Stata

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