PMID: 8603049Jan 1, 1996Paper

Reproductive phenotpes of the progesterone receptor null mutant mouse

The Journal of Steroid Biochemistry and Molecular Biology
J P LydonB W O'Malley

Abstract

Although progesterone has been traditionally associated with the establishment and maintenance of mammalian pregnancy, a number of studies have implicated physiological roles of this steroid hormone in other reproductive events. At present most of the downstream molecular and cellular mechanisms by which progesterone exerts its effects are unclear; however, the progesterone signal is known to be mediated initially by the progesterone receptor (PR), a member of the nuclear receptor superfamily of transcription factors. In most tissues studied, the PR is induced by ovarian estrogen via the estrogen receptor (ER), thereby implying that many of the observed reproductive physiological responses attributed to PR could conceivably be due to the combined effects of progesterone and estrogen. Therefore, to define clearly the distinct roles of progesterone and estrogen in vivo and to understand better progesterone function in a physiological context, we recently have generated a novel mouse strain in which both forms of the PR were ablated using gene targeting/embryonic stem cell techniques. Surprisingly, both male and female embryos, homozygous for the PR null mutation, developed to adulthood at the normal Mendelian frequency with no de...Continue Reading

References

Apr 1, 1977·The Journal of Endocrinology·T MoriA Kambegawa
Jan 1, 1992·Neurology·J J Halperin, M P Heyes
Oct 1, 1991·Human Reproduction·D LoutradisA Psychoyos
Jan 1, 1991·The Journal of Steroid Biochemistry and Molecular Biology·Y AkwaD H Jo
Jan 1, 1991·Psychoneuroendocrinology·C L Williams, W H Meck
Dec 1, 1990·American Journal of Reproductive Immunology : AJRI·J Szekeres-BarthoG Chaouat
May 1, 1990·Endocrine Reviews·C L Clarke, R L Sutherland
May 1, 1990·Endocrine Reviews·M A Carson-JuricaB W O'Malley
May 1, 1990·Endocrine Reviews·J C Prior
Aug 15, 1986·Science·O M ConneelyB W O'Malley
Jan 1, 1988·Journal of Steroid Biochemistry·B S McEwen
Sep 4, 1987·Science·C Le GoascogneM Waterman
Dec 16, 1987·Biochemical and Biophysical Research Communications·O M ConneelyB W O'Malley
Dec 1, 1985·Hormones and Behavior·A P Arnold, S M Breedlove
Aug 29, 1983·Brain Research·C J FredericksonJ B Kirkpatrick
Dec 16, 1982·Nature·T C RainbowB S McEwen
Sep 15, 1995·Genes & Development·J P LydonB W O'Malley
Jun 1, 1995·The Journal of Steroid Biochemistry and Molecular Biology·E BaldiG Forti
Jun 1, 1995·The Journal of Steroid Biochemistry and Molecular Biology·K B HorwitzG S Takimoto
Aug 1, 1995·Proceedings of the National Academy of Sciences of the United States of America·K L BrunerK G Osteen
Sep 8, 1995·Science·R KühnK Rajewsky
Jun 9, 1995·Science·H L KoenigE E Baulieu
Jan 1, 1994·Annual Review of Biochemistry·M J Tsai, B W O'Malley

❮ Previous
Next ❯

Citations

Jan 10, 2002·Journal of Biosciences·U Natraj
Jun 29, 2002·Molecular and Cellular Endocrinology·Meiyi TangLinda Tseng
Aug 29, 2003·The Journal of Steroid Biochemistry and Molecular Biology·J J Peluso
Sep 23, 1998·The Journal of Steroid Biochemistry and Molecular Biology·J Donath, Y Nishino
Feb 3, 2006·Biology of Reproduction·John J Peluso
Apr 9, 2008·Menopause : the Journal of the North American Menopause Society·Richard T Penson
Jan 6, 2011·Epilepsia·Alberto VerrottiFrancesco Chiarelli
Apr 13, 2002·Annals of the New York Academy of Sciences·Francesco J DeMayoSophia Y Tsai
Aug 24, 2001·The Journal of Clinical Investigation·R H KarasM E Mendelsohn
Nov 14, 2003·Reproductive Biology and Endocrinology : RB&E·Luiz E HenkesBo R Rueda
Nov 23, 2006·Reproductive Biology and Endocrinology : RB&E·Linda C Giudice
May 28, 2005·Endocrinology·Monica Muñoz-de-ToroAna M Soto
Nov 19, 2013·PLoS Genetics·Caterina ClementiMartin M Matzuk
Mar 23, 2005·Archives of Histology and Cytology·Gerald R CunhaTakeshi Kurita
Nov 9, 2011·Reproduction : the Official Journal of the Society for the Study of Fertility·Melissa E Pepling
Mar 8, 2005·Reproduction : the Official Journal of the Society for the Study of Fertility·S SukjumlongE Persson
Jan 3, 2006·Reproduction : the Official Journal of the Society for the Study of Fertility·Jennifer L JuengelKenneth P McNatty
Apr 26, 2000·Proceedings of the National Academy of Sciences of the United States of America·R L RobkerJ S Richards
Feb 12, 2014·Reproduction : the Official Journal of the Society for the Study of Fertility·John J Peluso, James K Pru
Nov 15, 2001·Proceedings of the National Academy of Sciences of the United States of America·L B LutzS R Hammes
Nov 18, 2006·Proceedings of the National Academy of Sciences of the United States of America·Osamu Wada-HiraikeJan-Ake Gustafsson
Aug 16, 2000·Proceedings of the National Academy of Sciences of the United States of America·J A ElvinM M Matzuk
Oct 16, 1999·Proceedings of the National Academy of Sciences of the United States of America·T A TibbettsB W O'Malley
Nov 10, 2001·Trends in Endocrinology and Metabolism : TEM·L Altucci, H Gronemeyer
Jun 3, 2008·Canadian Journal of Physiology and Pharmacology·Giyoun NaCheMyong Ko
May 4, 2011·Research in Veterinary Science·Natalia S AlfaroHugo H Ortega

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.