Reproductive, productivity, and mortality outcomes in late-gestation gilts and their litters following simulation of inadvertent exposure to a modified-live vaccine strain of porcine reproductive and respiratory syndrome (PRRS) virus

Adam SchelkopfScott A Dee


The study evaluated the safety of a modified live-virus (MLV) porcine reproductive and respiratory syndrome (PRRS) vaccine in susceptible, pregnant gilts. To simulate inadvertent exposure secondary to postvaccination shedding of PRRS-MLV, seronegative gilts (n=51) were exposed by IM vaccination at 90 days of gestation. Vaccinated and nonvaccinated, seronegative control gilts (n=25) were maintained in separate facilities. The PRRS-MLV vaccine was given in a 2mL dose on day 0. On day 7 all vaccinated gilts were PRRSV-PCR-positive for PRRSV and had responded serologically as determined by an ELISA. All control gilts remained PRRSV-PCR- and ELISA-negative throughout the study. Abortions did not occur in gilts from either group. The difference between vaccinated and control gilts in average number of piglets per litter (12.43 and 12.16, respectively), number of live births per litter (11.21 and 11.54), and mean piglet birth weight (3.22 and 3.26 lbs) were not significantly different. Piglets in the control group had significantly greater average daily gain versus piglets from vaccinated gilts (0.52 vs. 0.46 lbs, P<0.0001). Preweaning mortality was significantly greater (P=0.0023) in piglets from the vaccinated gilts (19.7% vs. 10.9%...Continue Reading


Nov 1, 1996·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·B R CageJ Portnoy
Aug 27, 2005·Journal of the American Veterinary Medical Association·Eric J NeumannJeffrey J Zimmerman
Aug 31, 2010·Virus Research·Michael P MurtaughFrederick C-C Leung
Sep 14, 2010·Virus Research·Raymond R R Rowland
Jul 23, 2013·Preventive Veterinary Medicine·Carmen AlonsoPeter R Davies

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