Reproductive safety evaluation of L-Ergothioneine

Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association
Roy ForsterJean-Claude Yadan

Abstract

L-Ergothioneine is a naturally occurring histidine-derived betaine (CAS No: 497-30-3) synthesized by bacteria and fungi, and found ubiquitously in plants and animals. It is present in many human foodstuffs. We evaluated the potential reproductive toxicity of L-Ergothioneine in Sprague-Dawley rats. L-Ergothioneine was administered at concentrations of 0.1, 0.3 or 0.9% in diet to F0 males (for 10 weeks before pairing and 3 weeks during pairing) and F0 females (for 13 weeks before pairing, during pairing and gestation, and until day 5 of lactation). Systemic exposure increased with dose-level, but not dose proportionally, suggesting saturation of uptake mechanisms. No clinical signs of toxicity were observed and there were no effects of L-Ergothioneine treatment on mating and reproductive performance or parameters of fertility. All animals mated within a similar number of days and pregnancy rates were uniformly high in control and treated groups. There were no effects of treatment with L-Ergothioneine on the duration of gestation, pre- and post-implantation losses, number of pups delivered and viability index, or on litter parameters (litter size, clinical signs, body weight or sex ratio) and the repartition of found dead/cannibal...Continue Reading

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Citations

Jun 17, 2016·International Journal of Toxicology·Palma Ann MaroneSteven Weisman
Jun 1, 2018·FEBS Letters·Barry HalliwellRichard M Y Tang
Feb 14, 2020·Nutrition Research Reviews·Irina BorodinaDouglas B Kell
Jul 11, 2020·Antioxidants·Irwin K Cheah, Barry Halliwell
Feb 10, 2021·Redox Biology·Irwin K Cheah, Barry Halliwell
May 22, 2020·Neuroscience and Biobehavioral Reviews·Ioannis ZalachorasLaia Morató
May 1, 2021·International Journal of Molecular Sciences·Colm J McElwainCathal M McCarthy
Dec 25, 2021·FEBS Letters·Lalitphan Kitsanayanyong, Toshiaki Ohshima

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