Reproductive technologies and the risk of birth defects

The New England Journal of Medicine
Michael J DaviesAnnabelle Chan

Abstract

The extent to which birth defects after infertility treatment may be explained by underlying parental factors is uncertain. We linked a census of treatment with assisted reproductive technology in South Australia to a registry of births and terminations with a gestation period of at least 20 weeks or a birth weight of at least 400 g and registries of birth defects (including cerebral palsy and terminations for defects at any gestational period). We compared risks of birth defects (diagnosed before a child's fifth birthday) among pregnancies in women who received treatment with assisted reproductive technology, spontaneous pregnancies (i.e., without assisted conception) in women who had a previous birth with assisted conception, pregnancies in women with a record of infertility but no treatment with assisted reproductive technology, and pregnancies in women with no record of infertility. Of the 308,974 births, 6163 resulted from assisted conception. The unadjusted odds ratio for any birth defect in pregnancies involving assisted conception (513 defects, 8.3%) as compared with pregnancies not involving assisted conception (17,546 defects, 5.8%) was 1.47 (95% confidence interval [CI], 1.33 to 1.62); the multivariate-adjusted odds ...Continue Reading

References

Jul 15, 1989·Lancet·A Czeizel
Mar 3, 2001·Human Reproduction·A Ericson, B Källén
Mar 8, 2002·The New England Journal of Medicine·Michèle HansenSandra Webb
Sep 21, 2002·Lancet·Michael Davies, Robert Norman
May 7, 2004·Current Opinion in Obstetrics & Gynecology·Jennifer J KurinczukCarol Bower
Jun 3, 2004·Obstetrics and Gynecology·Laura A SchieveVictoria C Wright
Nov 30, 2004·Human Reproduction·Michèle HansenJennifer J Kurinczuk
Jan 29, 2005·Birth Defects Research. Part A, Clinical and Molecular Teratology·Bengt KällénPetra Otterblad Olausson
Feb 12, 2005·Journal of Assisted Reproduction and Genetics·Alfred A RimmK Paul Katayama
Sep 20, 2005·Fertility and Sterility·Bengt KällénPetra Otterblad Olausson
Jun 1, 2006·Current Opinion in Obstetrics & Gynecology·Øjvind LidegaardAnders Nyboe Andersen
Aug 9, 2006·BMJ : British Medical Journal·Jin Liang ZhuJørn Olsen
Dec 14, 2006·Human Reproduction·Q YangM Walker
Jun 4, 2008·Fertility and Sterility·Shai E Elizur, Togas Tulandi
Nov 1, 2008·Fertility and Sterility·Darine El-ChaarMark Walker
Nov 18, 2008·Human Reproduction·J ReefhuisUNKNOWN National Birth Defects Prevention Study
Nov 13, 2010·Human Reproduction·Jennifer L MarinoMichael J Davies
Nov 30, 2010·Human Reproduction·J ReefhuisUNKNOWN National Birth Defects Prevention Study

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Citations

Dec 18, 2013·Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz·H KentenichA Tandler-Schneider
Mar 26, 2013·Journal of Assisted Reproduction and Genetics·David B BrownKathryn L Honea
Jun 14, 2013·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Vikram Sinai Talaulikar, Sabaratnam Arulkumaran
May 24, 2014·Journal of Pediatric Surgery·Stephen B Shew
Oct 16, 2013·Reproductive Biomedicine Online·Frauke Vanden MeerschautPetra De Sutter
Nov 26, 2013·Reproductive Biomedicine Online·Nino Guy CassutoGéraldine Viot
Oct 23, 2013·Reproductive Biomedicine Online·Daniel R BrisonSusan J Kimber
Dec 25, 2013·Reproductive Biomedicine Online·B C J M FauserUNKNOWN Evian Annual Reproduction (EVAR) Workshop Group 2011
Feb 25, 2014·Seminars in Fetal & Neonatal Medicine·Joe Leigh Simpson
Nov 24, 2012·Twin Research and Human Genetics : the Official Journal of the International Society for Twin Studies·S Alexandra Burt, Kelly L Klump
Nov 8, 2013·The New England Journal of Medicine·Carrie L WilliamsAlastair G Sutcliffe
Nov 14, 2012·Human Reproduction·A Maheshwari, S Bhattacharya
Mar 2, 2013·Human Reproduction Update·Michèle HansenCarol Bower
Dec 25, 2012·Molecular Human Reproduction·S K FeuerP F Rinaudo
Sep 20, 2012·Obstetrical & Gynecological Survey·Vikram Sinai Talaulikar, Sabaratnam Arulkumaran
Nov 21, 2012·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Takashi Kohda, Fumitoshi Ishino
Mar 27, 2013·Archives of Disease in Childhood. Fetal and Neonatal Edition·Jorien SeggersMijna Hadders-Algra
Jul 9, 2013·BMJ : British Medical Journal·Bjørn BayUlrik Schiøler Kesmodel
Sep 18, 2012·Orphanet Journal of Rare Diseases·Nadine ZwinkUNKNOWN CURE-Net Consortium
Aug 7, 2012·The Journal of Clinical Endocrinology and Metabolism·Elena LabartaAntonio Pellicer
Aug 24, 2013·International Journal of Environmental Research and Public Health·Kristen LyallCheryl K Walker
Sep 10, 2013·Western Pacific Surveillance and Response Journal : WPSAR·Louise FloodJoan Scott
Mar 7, 2014·The New England Journal of Medicine·Carrie L WilliamsAlastair G Sutcliffe
Nov 7, 2013·Reproduction : the Official Journal of the Society for the Study of Fertility·R John Aitken
May 9, 2014·Human Reproduction·Natalie WhitelawPaul Haggarty
May 20, 2014·Human Reproduction·Michael L EisenbergLarry I Lipshultz
Mar 11, 2015·Ontogenez·D S RagaevaS Ia Amstislavskiĭ
May 30, 2014·Journal of Assisted Reproduction and Genetics·UNKNOWN ESHRE Capri Workshop Group
Jun 20, 2013·Journal of Assisted Reproduction and Genetics·E RicciarelliS Fernández-Shaw
Jul 10, 2014·The New England Journal of Medicine·Richard S LegroUNKNOWN NICHD Reproductive Medicine Network
Oct 26, 2014·Orphanet Journal of Rare Diseases·Ingeborg BarisicHelen Dolk
Jul 9, 2013·Journal of Women's Health·Allison S MneimnehUNKNOWN States Monitoring ART (SMART) Collaborative

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