PMID: 8946561Nov 1, 1996Paper

Reproductive toxicity of cabergoline in mice, rats, and rabbits

Reproductive Toxicology
D BeltrameG Mazué

Abstract

Cabergoline, a new dopaminergic ergot derivative with potent long-lasting prolactin (PRL)-lowering properties, was assessed using standard reproductive studies in the mouse, rat, and rabbit with oral administration. Because of the compound's pharmacologic activity, several aspects remain incompletely explored in the rat, in which prolactin is the luteotrophic hormone. A fertility study in female rats was possible only at very low doses (0.5, 1, and 2 micrograms/kg/d) because higher doses completely inhibited implantation. In male rats no adverse effects were seen on male reproductive performance or on the offspring at doses up to 320 micrograms/kg/d given for 10 weeks prior to mating with untreated females. In a developmental toxicity study in rats treated from day 6 to day 15 of gestation at doses (6.25, 12.5, and 25 micrograms/kg/d) not exceeding the active dose for inhibition of egg nidation (ED50 = 25 micrograms/kg), a high incidence of total litter loss occurred as a reflection of inhibition of egg nidation at the highest dose, but embryofetal development was not impaired in litters reaching term. An exploratory study at 30 or 1000 micrograms/kg/d with treatment from day 5 of gestation or later demonstrated that cabergolin...Continue Reading

References

Sep 1, 1980·Journal of Reproduction and Fertility·D L MednickI I Geschwind

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Citations

Jul 1, 1996·Reproductive Toxicology·E RobertC I Ferrari
Oct 29, 2002·Reproductive Toxicology·Elena RicciMaurizio Bonati
Jul 6, 2014·Endocrine·Andrea Glezer, Marcello D Bronstein
Oct 9, 2012·Journal de gynécologie, obstétrique et biologie de la reproduction·I FatfoutaA Bongain
Sep 17, 2004·Movement Disorders : Official Journal of the Movement Disorder Society·Marco MucchiutPaolo Bergonzi
Aug 5, 2006·Clinical Endocrinology·Felipe F CasanuevaAndrea Giustina
Sep 17, 2011·Birth Defects Research. Part B, Developmental and Reproductive Toxicology·Brian P EnrightStephan J Kopytek

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