PMID: 8588947Nov 1, 1995Paper

Reproductive toxicity of chronic lead exposure in male and female mice

Human & Experimental Toxicology
G Pinon-LatailladeJ C Soufir

Abstract

The reproductive toxicity of lead was investigated in NMRI mice exposed to 0.5% lead acetate in drinking water from day 1 of intra-uterine life until 60 days after birth. Compared with control mice, the weights of lead-exposed fetuses and subsequently of the lead-exposed weaned pups, male and female, diminished by 11 and 13% respectively. The lead-exposed male and female offspring of lead-exposed dams were mated with unexposed females and males, to examine the effect of lead exposure on reproductive function. Male fertility was not affected but reduced female fertility was observed: litters were smaller and a smaller number of implantation sites was found in lead-exposed females. In lead-exposed males, the weights of the body, testes and epididymes diminished by about 13%, and seminal vesicle and ventral prostate weights, by about 29%. Testicular histology and the number and morphology of epididymal spermatozoa were normal. The levels of plasma FSH, LH and testosterone, and of testicular testosterone, were not modified. These results suggest that the hypothalamic-pituitary-testicular axis is not adversely affected by the above lead exposure, and that therefore the decreased seminal vesicle and ventral prostate weights might not...Continue Reading

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Citations

Feb 29, 2008·Journal of Toxicology and Environmental Health. Part a·Lu WangFeng Chen
Oct 9, 1998·Occupational and Environmental Medicine·P ApostoliM Vanhoorne
May 5, 2009·Journal of Endocrinological Investigation·K K DoumouchtsisD N Perrea
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Feb 16, 2018·Environmental Toxicology·Cuiling LiBiao Chen
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Jul 29, 2005·Toxicological Sciences : an Official Journal of the Society of Toxicology·Misaki KojimaMasakuni Degawa
Mar 14, 2020·International Journal of Environmental Research and Public Health·Sohyae LeeKyoung-Bok Min
Oct 28, 2020·Biological Trace Element Research·Zahra KhodabandehNegar Azarpira
Mar 17, 2021·Veterinary Medicine and Science·Rania A Abdel-Emam, Esraa A Ahmed
May 30, 2021·Journal of Biochemical and Molecular Toxicology·Jitender K BhardwajPriyanka Saraf

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