Reprogramming human cancer cells in the mouse mammary gland.

Cancer Research
Karen M BussardGilbert H Smith

Abstract

The tissue microenvironment directs stem/progenitor cell behavior. Cancer cells are also influenced by the microenvironment. It has been shown that, when placed into blastocysts, cancer cells respond to embryonic cues and differentiate according to the tissue type encountered during ontological development. Previously, we showed that the mouse mammary gland was capable of redirecting adult mouse testicular and neural stem/progenitor cells toward a mammary epithelial cell fate during gland regeneration. Here, we report that human embryonal carcinoma cells proliferate and produce differentiated mammary epithelial cell progeny when mixed with mouse mammary epithelial cells and inoculated into the epithelium-free mammary fat pads of athymic nude mice. Fluorescence in situ hybridization confirmed the presence of human cell progeny in the mammary outgrowths for human centromeric DNA, as well as immunochemistry for human-specific breast epithelial cytokeratins and human-specific milk proteins in impregnated transplant hosts. It was found that the number of human cells increased by 66- to 660-fold during mammary epithelial growth and expansion as determined by human cytokeratin expression. All features found in primary outgrowths were ...Continue Reading

References

Sep 1, 1975·Proceedings of the National Academy of Sciences of the United States of America·B Mintz, K Illmensee
Feb 1, 1976·Proceedings of the National Academy of Sciences of the United States of America·K Illmensee, B Mintz
Sep 1, 1992·The Japanese Journal of Human Genetics·S NagafuchiY Nakagome
Aug 3, 1988·Biochimica Et Biophysica Acta·P W Andrews
Oct 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·M GerschensonG B Pierce
Dec 23, 1998·Proceedings of the National Academy of Sciences of the United States of America·K D McCulloughJ W Grisham
Mar 16, 2007·Proceedings of the National Academy of Sciences of the United States of America·Corinne A BoulangerGilbert H Smith
Sep 24, 2008·Proceedings of the National Academy of Sciences of the United States of America·Brian W BoothGilbert H Smith

❮ Previous
Next ❯

Citations

Sep 9, 2010·Journal of Mammary Gland Biology and Neoplasia·Erin J McCaveBrian W Booth
May 15, 2012·Journal of Mammary Gland Biology and Neoplasia·Michael T LewisDaniel Medina
Aug 14, 2013·Journal of Biosciences·Carlos Sonnenschein, Ana M Soto
Jun 8, 2011·International Journal of Cell Biology·Karen M Bussard, Gilbert H Smith
Apr 17, 2014·Journal of Biosciences·Carlos SonnenscheinPrakash Kulkarni
Jan 22, 2014·Seminars in Cell & Developmental Biology·Beatrice A Howard, Pengfei Lu
Mar 3, 2012·EMBO Molecular Medicine·Paola BonfantiGiulio Cossu
Jul 12, 2014·Médecine sciences : M/S·Anna Zielinska, Tarik Issad
Apr 9, 2013·Pancreatology : Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]·Mert Erkan
Jul 17, 2012·Progress in Biophysics and Molecular Biology·G LongoA M Soto
Mar 21, 2012·Seminars in Cell & Developmental Biology·Robert D Bruno, Gilbert H Smith
May 31, 2011·Seminars in Cancer Biology·Carlos Sonnenschein, Ana M Soto
Nov 1, 2012·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·A SmorlesiS Cinti
Nov 19, 2011·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·Shuichi Fujita, Tohru Ikeda
Apr 20, 2011·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Ana M Soto, Carlos Sonnenschein
Apr 23, 2015·In Vitro Cellular & Developmental Biology. Animal·Jang Pyo ParkBrian W Booth
Feb 18, 2012·Drug Resistance Updates : Reviews and Commentaries in Antimicrobial and Anticancer Chemotherapy·Ana Luísa Correia, Mina J Bissell
Feb 18, 2012·Cancer Biology & Therapy·Antonia Artacho-CordónMaría Isabel Núñez
Dec 22, 2014·Journal of the National Cancer Institute·Stuart G Baker
Aug 9, 2016·Progress in Biophysics and Molecular Biology·Carlos Sonnenschein, Ana M Soto
Jan 5, 2017·International Journal of Cancer. Journal International Du Cancer·Jean-Pascal Capp
Feb 19, 2017·Cold Spring Harbor Perspectives in Medicine·Eishu Hirata, Erik Sahai
Nov 28, 2017·Journal of Biological Engineering·Patrick C SachsRobert D Bruno
Jan 10, 2017·Disease Models & Mechanisms·Jacob L Albritton, Jordan S Miller
Jun 14, 2013·Nature Reviews. Cancer·Mary Helen Barcellos-HoffTimothy C Wang
Nov 15, 2017·Royal Society Open Science·Marta Bertolaso, Anna Maria Dieli
Aug 11, 2020·Oncotarget·Anastasia Frank-KamenetskiiBrian W Booth
Feb 14, 2017·Stem Cells Translational Medicine·Juan Manuel IglesiasAngel G Martin
Nov 17, 2019·Journal of Mammary Gland Biology and Neoplasia·Anastasia Frank-Kamenetskii, Brian W Booth
Sep 18, 2015·American Journal of Physiology. Cell Physiology·Maren Pein, Thordur Oskarsson

❮ Previous
Next ❯

Related Concepts

Related Feeds

Adult Stem Cells

Adult stem cells reside in unique niches that provide vital cues for their survival, self-renewal, and differentiation. They hold great promise for use in tissue repair and regeneration as a novel therapeutic strategies. Here is the latest research.