PMID: 9529378May 16, 1998Paper

Reprogramming the cell cycle for endoreduplication in rodent trophoblast cells

Molecular Biology of the Cell
A MacAuleyZ Werb

Abstract

Differentiation of trophoblast giant cells in the rodent placenta is accompanied by exit from the mitotic cell cycle and onset of endoreduplication. Commitment to giant cell differentiation is under developmental control, involving down-regulation of Id1 and Id2, concomitant with up-regulation of the basic helix-loop-helix factor Hxt and acquisition of increased adhesiveness. Endoreduplication disrupts the alternation of DNA synthesis and mitosis that maintains euploid DNA content during proliferation. To determine how the mammalian endocycle is regulated, we examined the expression of the cyclins and cyclin-dependent kinases during the transition from replication to endoreduplication in the Rcho-1 rat choriocarcinoma cell line. We cultured these cells under conditions that gave relatively synchronous endoreduplication. This allowed us to study the events that occur during the transition from the mitotic cycle to the first endocycle. With giant cell differentiation, the cells switched cyclin D isoform expression from D3 to D1 and altered several checkpoint functions, acquiring a relative insensitivity to DNA-damaging agents and a coincident serum independence. The initiation of S phase during endocycles appeared to involve cycl...Continue Reading

References

Nov 1, 1992·Molecular Reproduction and Development·D L Chapman, D J Wolgemuth
Feb 1, 1991·Biology of Reproduction·T N FariaM J Soares
Feb 1, 1990·Experimental Cell Research·M Lalande
Aug 1, 1995·Chromosome Research : an International Journal on the Molecular, Supramolecular and Evolutionary Aspects of Chromosome Biology·T P Hartman, D I Southern
Sep 1, 1995·Molecular and Cellular Biology·R D BascoS I Reed
Mar 9, 1995·Nature·D O Morgan
Nov 18, 1994·Cell·R W KingM W Kirschner
Sep 6, 1994·Annals of the New York Academy of Sciences·P ReponenK Tryggvason
Jun 15, 1994·Biochemical and Biophysical Research Communications·I DamjanovJ A DeLoia
Sep 1, 1993·The Journal of Experimental Zoology·L H Hoffman, F B Wooding
Feb 1, 1993·Molecular Endocrinology·M M ShidaD I Linzer
Jan 1, 1997·Developmental Genetics·E Newman-Smith, Z Werb
Jan 1, 1997·Developmental Genetics·J L RinkenbergerZ Werb

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Citations

May 26, 2004·Biochimica Et Biophysica Acta·Yasuko TeraoYasushi Shintani
Feb 24, 2001·Theriogenology·J C Cross
Apr 1, 2000·Cytokine & Growth Factor Reviews·P M GrimleyH Rui
Oct 3, 2007·Nature Cell Biology·Marvin E Tanenbaum, René H Medema
Sep 25, 2007·Nature Cell Biology·David M J MartindillPaul R Riley
Dec 17, 2009·Proceedings of the National Academy of Sciences of the United States of America·Claude Gérard, Albert Goldbeter
Sep 16, 2003·Molecular Biology of the Cell·Ayelet LaronneMichael Brandeis
Dec 18, 2010·Human Reproduction·R UdayashankarH D Moore
Jul 8, 2011·Molecular Biology and Evolution·Coen CampsteijnEric M Thompson
Mar 7, 2003·Mutagenesis·Felipe Cortés, Nuria Pastor
Feb 17, 2006·Biology of Reproduction·Amy D GulticeThomas L Brown
Nov 29, 2008·Biology of Reproduction·L C SchulzR M Roberts
Sep 29, 1999·Genes & Development·J D SingerJ M Roberts
Mar 18, 2004·Science's STKE : Signal Transduction Knowledge Environment·Tin Tin Su, Jason Stumpff
Jul 31, 2002·Annual Review of Phytopathology·Godelieve Gheysen, Carmen Fenoll
May 29, 2012·Reproductive Biology and Endocrinology : RB&E·Katsuo KoshiKazuyoshi Hashizume
Jan 12, 2002·Biochemical and Biophysical Research Communications·Jun OhganeKunio Shiota
Mar 25, 2009·Reproduction : the Official Journal of the Society for the Study of Fertility·Sanjoy K Das
Mar 31, 1999·Proceedings of the National Academy of Sciences of the United States of America·Y SunB A Larkins
Apr 13, 2007·Chromosome Research : an International Journal on the Molecular, Supramolecular and Evolutionary Aspects of Chromosome Biology·Gianfranco CoppolaW Allan King
Apr 25, 2013·Proceedings of the National Academy of Sciences of the United States of America·Noa SherTerry L Orr-Weaver
Apr 28, 2004·Current Opinion in Genetics & Development·Huiping LiuKay Macleod
Jun 21, 2013·Hypertension in Pregnancy : Official Journal of the International Society for the Study of Hypertension in Pregnancy·Thajasvarie NaickerJagidesa Moodley
Feb 26, 2016·Current Biology : CB·James C Cross
Feb 10, 2009·Trends in Cell Biology·Tim LammensLieven De Veylder
Dec 15, 2015·Cell Death and Differentiation·H-C JuanM-J Fann

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