Repulsive axon guidance by Draxin is mediated by protein Kinase B (Akt), glycogen synthase kinase-3β (GSK-3β) and microtubule-associated protein 1B

PloS One
Rajeshwari MeliFriedrich Propst

Abstract

Draxin is an important axon guidance cue necessary for the formation of forebrain commissures including the corpus callosum, but the molecular details of draxin signaling are unknown. To unravel how draxin signals are propagated we used murine cortical neurons and genetic and pharmacological approaches. We found that draxin-induced growth cone collapse critically depends on draxin receptors (deleted in colorectal cancer, DCC), inhibition of protein kinase B/Akt, activation of GSK-3β (glycogen synthase kinase-3β) and the presence of microtubule-associated protein MAP1B. This study, for the first time elucidates molecular events in draxin repulsion, links draxin and DCC to MAP1B and identifies a novel MAP1B-depenent GSK-3β pathway essential for chemo-repulsive axon guidance cue signaling.

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Citations

Jan 17, 2016·Molecular and Cellular Neurosciences·Monia BarnatFatiha Nothias
Oct 10, 2015·Biochemical and Biophysical Research Communications·Wanlu ZhangCuifang Wang
Aug 2, 2018·Frontiers in Cellular Neuroscience·Alexa KissFriedrich Propst
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Jul 28, 2020·Frontiers in Cell and Developmental Biology·Santiago CuestaCecilia Flores
Feb 2, 2021·Frontiers in Cell and Developmental Biology·Satoru YamagishiKohji Sato
Feb 23, 2021·Frontiers in Physiology·Erica J HutchinsMarianne E Bronner
Aug 6, 2021·Frontiers in Cell and Developmental Biology·Sara A KirolosRichard H Gomer
Aug 6, 2021·Molecular Psychiatry·Andreas GötesonMikael Landén

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Methods Mentioned

BETA
FCS
myristoylation
transfection
electrophoresis
X-ray

Software Mentioned

image J
SPSS
ImageJ

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