Repulsive guidance molecule A (RGMa): a molecule for all seasons.

Cell Adhesion & Migration
Brian Key, Grace J Lah

Abstract

RGMa (repulsive guidance molecule a) was the first identified molecule that possessed the necessary functional activity to repulse and steer growth cones to their target in the brain. By binding to its neogenin receptor, RGMa caused the collapse of growth cones and encouraged axons to grow along specific trajectories in vitro. Although originally characterized in 1990, RGMa was not conclusively shown to mediate axon guidance in vivo for another 12 years. Loss-of-function analysis in mice revealed that RGMa may play a more important role in neural tube morphogenesis. RGMa has now emerged as a molecule with pleiotropic roles involving cell adhesion, cell migration, cell polarity and cell differentiation which together strongly influence early morphogenetic events as well as immune responses. RGMa can be regarded as a molecule for all seasons.

References

Nov 1, 1996·Current Biology : CB·B K MüllerF Bonhoeffer
Aug 7, 2001·Frontiers in Bioscience : a Journal and Virtual Library·T P FlemingI Fesenko
Sep 28, 2002·Nature·Philippe P MonnierBernhard K Mueller
Oct 1, 1963·Proceedings of the National Academy of Sciences of the United States of America·R W SPERRY
Dec 18, 2003·Gene Expression Patterns : GEP·Jens Schmidtmer, Dieter Engelkamp
Jan 30, 2004·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Vera NiederkoflerSilvia Arber
Feb 27, 2004·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Tarek A SamadClifford J Woolf
Jan 24, 2006·Developmental Biology·Dana RashidRoger Bradley
Apr 6, 2006·The Journal of Cell Biology·Katsuhiko HataToshihide Yamashita
Nov 28, 2008·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Nigel KeeHelen M Cooper
Mar 23, 2011·Nature Medicine·Rieko MuramatsuToshihide Yamashita
Apr 7, 2011·Proceedings of the National Academy of Sciences of the United States of America·Valbona MirakajJan M Schwab
Jan 5, 2012·Molecular and Cellular Biology·Grace J Lah, Brian Key
Feb 22, 2012·Developmental Cell·Nardos G TassewPhilippe P Monnier

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Citations

Apr 30, 2019·Frontiers in Genetics·Brigitte ReimannMichelle Plusquin
Sep 26, 2020·Current Biology : CB·Denis V TikhonenkovPatrick J Keeling

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