Repurposing an Old Drug for a New Epidemic: Ursodeoxycholic Acid to Prevent Recurrent Clostridioides difficile Infection

Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America
Brandon J WebbBert K Lopansri

Abstract

Recurrent Clostridioides difficile infection (rCDI) may be mediated in part by secondary bile acids. Here we report salvage therapy with ursodeoxycholic acid (UDCA) to prevent rCDI in 16 high-risk patients. Patients on UDCA had a low observed recurrence rate (12.5%). Controlled trials are needed to confirm these observations.

References

Jul 7, 2012·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Erik R Dubberke, Margaret A Olsen
Nov 21, 2012·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·C P Kelly
Jan 30, 2015·Infection Control and Hospital Epidemiology : the Official Journal of the Society of Hospital Epidemiologists of America·Abhishek DeshpandeThomas G Fraser
Apr 19, 2016·Alimentary Pharmacology & Therapeutics·J R AllegrettiJ R Korzenik
Jun 19, 2016·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Nicholas W Van HiseFarrin A Manian
Sep 14, 2016·The American Journal of Gastroenterology·Alex CarignanJacques Pépin
Nov 29, 2016·JAMA : the Journal of the American Medical Association·Victoria HansenHeidi E Brown
Jan 26, 2017·The New England Journal of Medicine·Mark H WilcoxUNKNOWN MODIFY I and MODIFY II Investigators
Mar 15, 2018·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Dale N GerdingMary Beth Dorr

❮ Previous
Next ❯

Citations

Aug 27, 2019·Therapeutic Advances in Infectious Disease·Robert Orenstein, Roberto L Patron
Jul 1, 2020·American Journal of Physiology. Gastrointestinal and Liver Physiology·Xi QianCheleste M Thorpe
Nov 3, 2020·Open Forum Infectious Diseases·Kayla R StoverChristopher M Bland
Apr 10, 2021·Saudi Journal of Gastroenterology : Official Journal of the Saudi Gastroenterology Association·Zhengjun WangWen Wang
Jul 5, 2021·Alimentary Pharmacology & Therapeutics·Sarah Rotondo-TrivetteSonia Michail

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.