Repurposing cefuroxime for treatment of COVID-19: a scoping review of in silico studies.

Journal of Biomolecular Structure & Dynamics
Ashimiyu B DurojaiyeCan Wang

Abstract

Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), the causative agent of Coronavirus disease 19 (COVID-19), is a novel human Coronavirus that is responsible for about 300,000 deaths worldwide. To date, there is no confirmed treatment or vaccine prevention strategy against COVID-19. Due to the urgent need for effective treatment, drug repurposing is regarded as the immediate option. Potential drugs can often be identified via in silico drug screening experiments. Consequently, there has been an explosion of in silico experiments to find drug candidates or investigate anecdotal claims. One drug with several anecdotal accounts of benefit is Cefuroxime. The aim of this study was to identify and summarize in silico evidence for possible activity of Cefuroxime against SARS-CoV-2.To this end, we performed a scoping review of literature of in silico drug repurposing experiments for SARS-CoV-2 using PRISMA-ScR. We searched Medline, Embase, Scopus, Web of Knowledge, and Google Scholar for original studies published between 1st Feb, 2020 and 15th May, 2020 that screened drug libraries, and identified Cefuroxime as a top-ranked potential inhibitor drug against SARS-CoV-2 proteins. Six studies were identified. These studies repo...Continue Reading

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Citations

Jan 14, 2021·Journal of Biomolecular Structure & Dynamics·Khadijeh AhmadiHamid Madanchi
Apr 30, 2021·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Shaomin Yan, Guang Wu
May 23, 2021·Annals of Clinical Microbiology and Antimicrobials·Abdourahamane YacoubaIsmaeel Yunusa
Jan 29, 2022·Signal Transduction and Targeted Therapy·Weizhu YanWei Cheng

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Methods Mentioned

BETA
MDS

Software Mentioned

Embase
MDS
Prime MM - GBSA
Remdesivir
of
Google Scholar
Web
Scopus
MatchMaker

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