Repurposing Drugs in Oncology (ReDO)-diclofenac as an anti-cancer agent

Ecancermedicalscience
Pan PantziarkaVikas P Sukhatme

Abstract

Diclofenac (DCF) is a well-known and widely used non-steroidal anti-inflammatory drug (NSAID), with a range of actions which are of interest in an oncological context. While there has long been an interest in the use of NSAIDs in chemoprevention, there is now emerging evidence that such drugs may have activity in a treatment setting. DCF, which is a potent inhibitor of COX-2 and prostaglandin E2 synthesis, displays a range of effects on the immune system, the angiogenic cascade, chemo- and radio-sensitivity and tumour metabolism. Both pre-clinical and clinical evidence of these effects, in multiple cancer types, is assessed and summarised and relevant mechanisms of action outlined. Based on this evidence the case is made for further clinical investigation of the anticancer effects of DCF, particularly in combination with other agents - with a range of possible multi-drug and multi-modality combinations outlined in the supplementary materials accompanying the main paper.

Citations

Jun 21, 2019·Science Translational Medicine·Christopher W McAleerJames J Hickman
Jan 21, 2020·Cancer Science·Takaaki MasudaKoshi Mimori
Oct 15, 2019·European Journal of Cancer Prevention : the Official Journal of the European Cancer Prevention Organisation (ECP)·Marisa CoelhoMarco Cosentino
Jun 6, 2018·Frontiers in Physiology·Beste TuranliAdil Mardinoglu
Jul 25, 2019·Frontiers in Oncology·Katrin SingerElisabeth Datz
Sep 8, 2018·Frontiers in Oncology·Henry T Marshall, Mustafa B A Djamgoz
Dec 11, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Zlatko Dembic
Jul 30, 2021·World Journal of Gastrointestinal Oncology·Hande BeklenKazim Yalcin Arga
Aug 28, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Wanda Baer-DubowskaVioletta Krajka-Kuźniak
Oct 7, 2021·Environmental Science and Pollution Research International·Smita KumariRashmi K Ambasta

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Methods Mentioned

BETA
xenograft
xenografts
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