Repurposing screens of FDA-approved drugs identify 29 inhibitors of SARS-CoV-2

Journal of Microbiology and Biotechnology
Keun Bon KuChonsaeng Kim

Abstract

COVID-19, caused by a novel coronavirus, SARS-CoV-2, has spread globally and caused serious social and economic problems. The WHO has declared this outbreak a pandemic. Currently, there are no approved vaccines or antiviral drugs. Drugs already approved for clinical use would be ideal candidates for rapid development as COVID-19 treatments. In this work, we screened 1,473 FDA-approved drugs to identify inhibitors of SARS-CoV-2 infection using cell-based assays. The antiviral activity of each compound was measured based on the immunofluorescent staining of infected cells using anti-dsRNA antibody. Twenty-nine drugs were found to show antiviral activity against SARS-CoV-2. We report this new list of inhibitors to quickly provide basic information for consideration in developing potential therapies.

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Citations

Jul 28, 2021·Journal of Chemical Information and Modeling·Hazem MslatiArtem Cherkasov

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