Required propofol dose for anesthesia and time to emerge are affected by the use of antiepileptics: prospective cohort study

BMC Anesthesiology
Kentaro Ouchi, Kazuna Sugiyama

Abstract

We investigated the impact of the type of neurological disorder on the required propofol dose for anesthesia and the time to emerge from anesthesia during dental treatment in patients with autism (AU), cerebral palsy (CP), and intellectual disability (ID), some of whom also had epilepsy. We studied 224 patients with a neurological disorder who underwent dental treatment under intravenous general anesthesia. Patients were categorized according to neurological disorder (AU, CP, and ID; and with or without an antiepileptic). The propofol dose required for anesthesia, time to emerge, and modeled propofol blood concentration at emergence were evaluated. In patients not given an antiepileptic, we found no significant differences in the propofol dose, modeled propofol blood concentration at emergence, or time to emerge among patients with AU, CP, and ID (P > 0.05). When using an antiepileptic, the dose of propofol (5.7 ± 1.51 mg/kg/h) was significantly lower than without an antiepileptic (6.8 ± 1.27 mg/kg/h) (P < 0.0001). The modeled propofol blood concentration at emergence in patients given an antiepileptic (0.5 ± 0.03 μg/ml) was significantly lower than without an antiepileptic (0.7 ± 0.02 μg/ml) (P < 0.0001). The time to emerge in...Continue Reading

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Citations

Jan 14, 2016·Journal of Clinical Monitoring and Computing·Kentaro OuchiKazuna Sugiyama
Jun 29, 2016·Epilepsia·Adys MendizabalAllison W Willis
Feb 9, 2017·Paediatric Anaesthesia·Melanie BloorMark Thomas
Mar 6, 2018·Southern Medical Journal·Khaled DajaniKierstin Lund
Apr 27, 2020·British Journal of Pharmacology·Guang-Ming WangZhe Zhang
Aug 25, 2020·Anesthesia and Analgesia·Steven P BrandtPatrick L Purdon
Jul 11, 2018·Frontiers in Systems Neuroscience·Elisa C WalshPatrick L Purdon
Dec 2, 2017·Journal of Intellectual Disability Research : JIDR·H HiguchiT Miyawaki
Sep 15, 2020·Anesthesia and Analgesia·Steven P BrandtPatrick L Purdon
Apr 22, 2021·Journal of Dental Anesthesia and Pain Medicine·Junglim Choi, Re-Mee Doh
Jun 18, 2021·Journal of Dental Anesthesia and Pain Medicine·Junglim Choi, Seungoh Kim

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