required to maintain repression2 is a novel protein that facilitates locus-specific paramutation in maize.

The Plant Cell
Joy-El R BarbourJ B Hollick

Abstract

Meiotically heritable epigenetic changes in gene regulation known as paramutations are facilitated by poorly understood trans-homolog interactions. Mutations affecting paramutations in maize (Zea mays) identify components required for the accumulation of 24-nucleotide RNAs. Some of these components have Arabidopsis thaliana orthologs that are part of an RNA-directed DNA methylation (RdDM) pathway. It remains unclear if small RNAs actually mediate paramutations and whether the maize-specific molecules identified to date define a mechanism distinct from RdDM. Here, we identify a novel protein required for paramutation at the maize purple plant1 locus. This required to maintain repression2 (RMR2) protein represents the founding member of a plant-specific clade of predicted proteins. We show that RMR2 is required for transcriptional repression at the Pl1-Rhoades haplotype, for accumulation of 24-nucleotide RNA species, and for maintenance of a 5-methylcytosine pattern distinct from that maintained by RNA polymerase IV. Genetic tests indicate that RMR2 is not required for paramutation occurring at the red1 locus. These results distinguish the paramutation-type mechanisms operating at specific haplotypes. The RMR2 clade of proteins p...Continue Reading

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Citations

Mar 21, 2013·The Plant Cell·Karl F ErhardJay B Hollick
Oct 23, 2013·PLoS Genetics·Christiane L BeleleVicki L Chandler
Sep 1, 2015·Seminars in Cell & Developmental Biology·Janelle M Gabriel, Jay B Hollick
Sep 1, 2015·Seminars in Cell & Developmental Biology·Iris HövelMaike Stam
Sep 4, 2015·Seminars in Cell & Developmental Biology·Roberto Pilu
Apr 1, 2014·Cell·Edith Heard, Robert A Martienssen
Sep 29, 2012·Current Opinion in Plant Biology·Jay B Hollick
Jan 24, 2015·Current Opinion in Biotechnology·Jerzy Paszkowski
Nov 1, 2016·Nature Reviews. Genetics·Jay B Hollick
Jan 19, 2013·Nature Reviews. Genetics·Stephane E Castel, Robert A Martienssen
Feb 6, 2015·Genetics·Karl F ErhardJay B Hollick
Apr 19, 2018·Nature Reviews. Endocrinology·Elizabeth J Radford

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