PMID: 8958130Jan 1, 1997Paper

Requirement for, promotion, or inhibition by alpha-tocopherol of radical-induced initiation of plasma lipoprotein lipid peroxidation

Free Radical Biology & Medicine
J NeuzilR Stocker

Abstract

alpha-Tocopherol (alpha-TOH), generally regarded as the most important lipid-soluble, chain-breaking antioxidant in human plasma, can also be a pro-oxidant in isolated low-density lipoprotein (LDL) (Bowry V. W.; Stocker R. J. Am. Chem. Soc. 115:6029-6044; 1993). Here we examined whether this pro-oxidant activity of alpha-TOH is of more general relevance. We compared the oxidizability of lipid hydroperoxide-free, in vivo or in vitro alpha-TOH-depleted LDL and high-density lipoprotein (HDL), as well as plasma reconstituted with alpha-TOH-depleted lipoproteins, with that of the corresponding native and alpha-TOH-supplemented samples, using water- and lipid-soluble peroxyl radicals (ROO.), hydroxyl radicals (.OH), Cu2+, the transition metal-containing Ham's F-10 medium, soybean 15-lipoxygenase, and horseradish peroxidase as oxidants. Lipoprotein and plasma oxidizability was assessed by the loss of cholesteryl esters and alpha-TOH and the accumulation of hydroperoxides of cholesteryl esters and phospholipids. Compared to native LDL, HDL, and plasma, the in vivo and in vitro alpha-TOH-depleted counterparts were highly resistant to peroxidation initiation by all oxidants when used at mild radical flux conditions. Wherever tested, the ...Continue Reading

References

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Citations

Jul 23, 1999·BioFactors·S R ThomasR Stocker
Jul 23, 1999·BioFactors·A KontushU Beisiegel
Dec 8, 2004·Molecular Nutrition & Food Research·Claus Schneider
Mar 1, 2002·Bulletin of Mathematical Biology·C A CobboldS R J Maxwell
Mar 4, 2008·Journal of Physiology and Biochemistry·M CiocoiuI Paduraru
Jan 1, 2010·Indian Journal of Clinical Biochemistry : IJCB·Mohammad Ali Ghaffari, T Ghiasvand
Nov 19, 2003·Archives of Biochemistry and Biophysics·Stéphanie ZarevPatrice Thérond
Dec 23, 2003·Clinica Chimica Acta; International Journal of Clinical Chemistry·Ntei AbuduStanley S Levinson
May 28, 2005·Cytokine·Anna Maria Witkowska
May 28, 2004·Diabetes Research and Clinical Practice·Maryam Sadat FarvidNavid Saadat
Nov 5, 2003·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Deodato AssanelliFrancesco Visioli
Aug 29, 1997·Chemistry and Physics of Lipids·B KartenA Kontush
Aug 29, 1998·Chemistry and Physics of Lipids·J N HerakJ Marincel
Jun 20, 2003·Progress in Lipid Research·Joanne M UpstonRoland Stocker
Apr 3, 2003·Cancer Detection and Prevention·R E J Mitchel, R A McCann
Aug 18, 2000·Free Radical Biology & Medicine·S R Thomas, R Stocker
Oct 18, 2000·Free Radical Biology & Medicine·P K WittingR Stocker
Nov 7, 2000·Free Radical Biology & Medicine·H O MowriJ F Keaney
Jun 8, 2001·Free Radical Biology & Medicine·M J ThomasL L Rudel
Jan 1, 1997·Free Radical Biology & Medicine·J M ProudfootL J Beilin
Apr 29, 1998·Free Radical Biology & Medicine·O ZiouzenkovaH Esterbauer
Jun 15, 1999·Trends in Biochemical Sciences·R Stocker
Oct 2, 2008·The British Journal of Nutrition·S Honarbakhsh, M Schachter
Apr 20, 2002·The Biochemical Journal·Joanne M UpstonRoland Stocker
Mar 7, 2001·Antioxidants & Redox Signaling·O TiroshR Kohen
May 5, 1998·Fundamental & Clinical Pharmacology·M K WalkerL Rochette

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