Requirement for ribosome-releasing factor for the release of ribosomes at the termination codon.

European Journal of Biochemistry
K Ogawa, Akira Kaji

Abstract

With the use of 3H-labeled R 17 amB2 phage RNA having an UAG codon at the seventh triplet of the coat cistron, release of the RNA from ribosomes at the termination codon was studied. The ribosome-releasing factor previously described was shown to stimulate the process of mRNA release at the termination factor (RF-1). GTP was required for this process and guanosine 5'-(beta,gamma-methylene)triphosphate could not replace GTP. No apparent change of size of R 17 RNA was observed during the release of the R 17 RNA from the ribosomes. The ribosome-releasing factor is distinct from the known termination codon-specific factor such as RF-1.

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Citations

Aug 1, 1977·Proceedings of the National Academy of Sciences of the United States of America·H F KungH Weissbach
Oct 1, 1981·Proceedings of the National Academy of Sciences of the United States of America·M RyojiA Kaji
May 10, 1994·Proceedings of the National Academy of Sciences of the United States of America·L JanosiA Kaji
Jul 19, 2000·The EMBO Journal·Y InokuchiA Kaji
Feb 14, 2012·Journal of Molecular Biology·Serafín Vivanco-DomínguezGabriel Guarneros
Jan 24, 2007·Molecular Microbiology·Gregory S Allen, Joachim Frank
Feb 21, 2006·Trends in Biochemical Sciences·Go HirokawaAkira Kaji
Feb 26, 2000·Annual Review of Genetics·P Hilleren, R Parker
Sep 10, 2003·The Journal of Biological Chemistry·Michael C KielAkira Kaji
Jun 16, 1978·Molecular Biology Reports·A P SurguchovL V Lyzlova
Feb 5, 2000·Journal of Molecular Biology·L JanosiA Kaji
Dec 25, 1983·Journal of Molecular Biology·J R Menninger

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