Requirement for specific gravity and creatinine adjustments for urinary steroids and luteinizing hormone concentrations in adolescents

Annals of Clinical Biochemistry
Gurmeet K S SinghDavid J Handelsman

Abstract

Urinary hormone concentrations are often adjusted to correct for hydration status. We aimed to determine whether first morning void urine hormones in growing adolescents require adjustments and, if so, whether urinary creatinine or specific gravity are better adjustments. The study population was adolescents aged 10.1 to 14.3 years initially who provided fasting morning blood samples at 0 and 12 months (n = 343) and first morning urine every three months (n = 644). Unadjusted, creatinine and specific gravity-adjusted hormonal concentrations were compared by Deming regression and Bland-Altman analysis and grouped according to self-rated Tanner stage or chronological age. F-ratios for self-rated Tanner stages and age groups were used to compare unadjusted and adjusted hormonal changes in growing young adolescents. Correlations of paired serum and urinary hormonal concentration of unadjusted and creatinine and specific gravity-adjusted were also compared. Fasting first morning void hormone concentrations correlated well and were unbiased between unadjusted or adjusted by either creatinine or specific gravity. Urine creatinine concentration increases with Tanner stages, age and male gender whereas urine specific gravity was not inf...Continue Reading

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Citations

Sep 17, 2019·Clinical Pediatrics·Ben W R BalzerKatharine S Steinbeck
Mar 8, 2019·Journal of Lipid Research·Cristina GómezCraig E Wheelock
Feb 6, 2020·Journal of the Endocrine Society·Katharine S SteinbeckDavid J Handelsman
Sep 7, 2019·International Journal of Environmental Health Research·Patricia A JanulewiczJunenette L Peters

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Methods Mentioned

BETA
urine collected
urine void
urine collection

Software Mentioned

SPSS
MedCalc

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