PMID: 6980255Aug 1, 1982Paper

Requirement for three signals in B cell responses. II. Analysis of antigen- and Ia-restricted T helper cell-B cell interaction

The Journal of Experimental Medicine
R H Zubler, O Kanagawa

Abstract

We have recently reported that resting B cells must receive at least three different signals in a T helper cell (TH)-dependent as well as in a lipopolysaccharide (LPS)-induced B cell response (3), i.e., a specific TH signal (that can be bypassed by LPS), a nonspecific TH signal (mediated by Ia or antigen-nonspecific B cell helper factor), and an antigen (hapten) signal. In a system using male (H-Y) antigen-specific cloned TH of C57BL/6 origin and male (or female) B cells, we now confirm and extend these findings by demonstrating that H-Y-specific TH must see both H-Y and Ia determinants on the B cells (and not only on macrophages) to provide the first specific TH signal required for a plaque-forming cell (PFC) response. This signal was interfered with by a monoclonal anti-I-Ab antibody at the B cell level, was not mediated by detectable soluble factors (in contrast to the nonspecific signal also provided by the TH), and could be bypassed by LPS, in which case anti-I-Ab antibody had no effect. However, although the H-Y-specific TH induced a polyclonal PFC response (B cell differentiation) in the apparent absence of an antigen seen by the B cells, significant clonal expansion of PFC precursors occurred only when the B cells also ...Continue Reading

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Citations

Jan 1, 1986·Springer Seminars in Immunopathology·R H ZublerP A Miescher
Dec 1, 1987·Veterinary Immunology and Immunopathology·H Salmon
Jun 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·R PalaciosK Guy
Sep 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·M L JelachichS K Pierce
Mar 1, 1984·The Journal of Experimental Medicine·A L DeFrancoW E Paul
Oct 1, 1984·The Journal of Experimental Medicine·R H ZublerH R MacDonald
Jan 1, 1984·Journal of Interferon Research·C S ReissS L Mowshowitz
Jan 1, 1985·Scandinavian Journal of Gastroenterology. Supplement·P Brandtzaeg
Oct 1, 1987·Immunological Reviews·B Jones
Oct 1, 1987·Immunological Reviews·R H ZublerC Straub
Oct 1, 1987·Immunological Reviews·E C Snow, R J Noelle
Oct 1, 1987·Immunological Reviews·T LeandersonR Rajasekar
Apr 1, 1984·Immunological Reviews·A CoutinhoC Martinez
Oct 1, 1984·Scandinavian Journal of Immunology·M ZöllerG Andrighetto
Jul 1, 1985·Scandinavian Journal of Immunology·M ZöllerG Andrighetto
Nov 1, 1988·Scandinavian Journal of Immunology·R RajasekarT Leanderson
Sep 1, 1983·Scandinavian Journal of Immunology·G PoborA Coutinho
Dec 23, 1998·European Journal of Immunology·M C CookB Fazekas de St Groth
Apr 1, 1986·European Journal of Immunology·P PereiraA Coutinho
Sep 1, 1988·European Journal of Immunology·K SekitaR H Zubler
Feb 1, 1989·European Journal of Immunology·S R CardingK Bottomly
May 22, 2021·Pharmacological Reviews·Samantha Christine SernoskieJack Paul Uetrecht

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