PMID: 1165473Sep 1, 1975Paper

Requirement for vasoactive amines for production of delayed-type hypersensitvity skin reactions

The Journal of Experimental Medicine
R K GershonM D Gershon

Abstract

The skin sites of the mouse where delayed-type hypersensitivity (DTH) reactions are most easily elicited (foot pads and ears) are particularly rich in 5-hydroxytryptamine (5-HT)-containing mast cells. Since mice are deficient in circulating basophils, which play a role in at least some DTH reactions, we investigated the possibility that the mast cells were playing an important role in the evolution of the skin reactions of DTH in mice. We found that reserpine, a drug which depletes mast cells of 5-HT, abolished the ability of the mouse to make DTH reactions in the skin. The suppressive effect of reserpine could be partially blocked by monoamine oxidase inhibitors which prevent the degradation of 5-HT in the cytosol of the mast cell. Spleen cells of immune, reserpine-treated mice transferred DTH reactions to nonimmune mice normally, indicating that the reserpine treatment did not affect immune T cells. DTH reactions could not be transferred into reserpine-treated mice. We suggest that T cells are continually emigrating from the blood, through postcapillary venule endothelium, by a mechanism which does not depend on vasoactive amines. If they are appropriately immune and meet the homologous antigen in the tissue, they induce mast...Continue Reading

References

Jul 15, 1972·Lancet·R A Kaslow, S R Zellner
Jul 3, 1974·Naunyn-Schmiedeberg's Archives of Pharmacology·A GiachettiP A Shore
Jan 1, 1966·International Archives of Allergy and Applied Immunology·B Gözsy, L Kátó
Jan 1, 1969·Transplantation Reviews·J F Miller, G F Mitchell
Jan 1, 1967·Histochemie. Histochemistry. Histochimie·K Fuxe, G Jonsson
Jul 1, 1968·British Journal of Pharmacology and Chemotherapy·A B Drakontides, M D Gershon
Aug 1, 1966·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·P DukorP Loustalot
Feb 18, 1967·Nature·R K GershonK Kondo
Aug 1, 1967·Experimental Cell Research·B Ehinger, R Thunberg
Aug 1, 1956·Proceedings of the Society for Experimental Biology and Medicine·M A FINK
Jan 1, 1957·Journal of Neuropathology and Experimental Neurology·L H BOGDANOVE, G CLARK
Jul 1, 1963·Journal of Neuropathology and Experimental Neurology·T U KOSUNENI K SAMUELSSON
Sep 1, 1963·The Journal of Experimental Medicine·J S NAJARIAN, J D FELDMAN
Jan 14, 1964·Proceedings of the Royal Society of London. Series B, Containing Papers of a Biological Character·V T MARCHESI, J L GOWANS
Apr 1, 1964·The Journal of Cell Biology·D A FISCHMAN, M D GERSHON
Dec 1, 1961·The Journal of Biophysical and Biochemical Cytology·G MAJNOG I SCHOEFL
Jan 14, 2004·The Journal of Pharmacology and Experimental Therapeutics·Hong-Zhen HuJackie D Wood

❮ Previous
Next ❯

Citations

Oct 1, 1991·Journal of Applied Toxicology : JAT·I KimberJ W Coleman
Sep 1, 1983·Inflammation·S Wescott, M Kaliner
Dec 1, 1980·Acta Tropica. Supplementum·L Haller
Jun 1, 1980·Immunopharmacology·A SchwartzR K Gershon
Jun 1, 1984·Immunopharmacology·N BloksmaJ M Willers
Jan 1, 1985·International Journal of Immunopharmacology·I PaegelowP Lange
Nov 1, 1989·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·I Kimber
Apr 1, 1986·Clinics in Dermatology·S M Breathnach
Sep 1, 1988·Journal of Photochemistry and Photobiology. B, Biology·L K RobertsB D Jun
Mar 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·W PtakR K Gershon
Sep 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·C F BrosnanW T Norton
Nov 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·L M KleinG F Murphy
Jan 1, 1977·Avian Pathology : Journal of the W.V.P.A·M E Rose, J W Bradley
Jan 1, 1987·Avian Pathology : Journal of the W.V.P.A·V Huynh, R C Chubb
Mar 1, 1976·The Journal of Experimental Medicine·C G Romball, W O Weigle
Nov 2, 1976·The Journal of Experimental Medicine·W R ThomasM C Watkins
Jan 1, 1977·The Journal of Experimental Medicine·J B Hay, B B Hobbs
Nov 1, 1980·The Journal of Experimental Medicine·P W AskenaseR K Gershon
Mar 1, 1983·The Journal of Experimental Medicine·P W AskenaseW Ptak
May 1, 1983·The Journal of Experimental Medicine·H van LoverenP W Askenase
Mar 1, 1979·International Journal of Dermatology·H Nagaya
Sep 8, 2006·Immunology and Cell Biology·Shisan BaoAlan J Husband
Sep 1, 1990·The Japanese Journal of Psychiatry and Neurology·T ShimomuraK Takahashi
Jan 1, 1978·Immunological Reviews·A K SobotkaL M Lichtenstein
Dec 29, 2000·Journal of Clinical Pathology·I S Roberts, P E Brenchley
Feb 13, 2001·Experimental Dermatology·B M HenzM Babina
Jul 1, 1984·Journal of Pharmacological Methods·J P TarayreH Lauressergues

❮ Previous
Next ❯

Related Concepts

Related Feeds

Basophils

Basophils are myeloid cells with a high affinity IgE receptor and is involved in inflammatory responses during allergy. Discover the latest research on Basophils here.