Requirement of CDC42 for Salmonella-induced cytoskeletal and nuclear responses

Science
L M ChenJorge E Galán

Abstract

The bacterial pathogen Salmonella typhimurium triggers host cell signaling pathways that lead to cytoskeletal and nuclear responses required for pathogenesis. Here, the role of the small guanosine triphosphate (GTP)-binding protein CDC42Hs in these responses was examined. Expression of a dominant interfering mutant of CDC42 (CDC42HsN17) prevented S. typhimurium-induced cytoskeletal reorganization and subsequent macropinocytosis and bacterial internalization into host cells. Cells expressing constitutively active CDC42 (CDC42HsV12) internalized an S. typhimurium mutant unable to trigger host cell responses. Furthermore, expression of CDC42HsN17 prevented S. typhimurium-induced JNK kinase activation. These results indicate that CDC42 is required for bacterial invasion and induction of nuclear responses in host cells.

References

Jul 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·C GinocchioJ E Galán
Nov 1, 1990·The Journal of Infectious Diseases·B B Finlay, S Falkow
May 25, 1990·Science·A Gibbons
Nov 24, 1995·The Journal of Biological Chemistry·S BagrodiaR A Cerione
Jun 16, 1995·Cell·M P PeppelenboschJ L Bos
Feb 23, 1995·Nature·R HeimR Y Tsien
Oct 1, 1994·Infection and Immunity·F Garcia-del Portillo, B B Finlay
Jan 1, 1994·Methods in Enzymology·J P Van PuttenH U Grassmé
Nov 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·B D JonesS Falkow
Apr 1, 1996·Molecular Microbiology·J E Galán
Feb 1, 1996·Current Opinion in Cell Biology·S H Zigmond
Sep 1, 1996·Molecular Microbiology·L M ChenJ E Galán

❮ Previous
Next ❯

Citations

Jul 13, 1999·Cell Motility and the Cytoskeleton·L B ChristersonM H Cobb
Jun 22, 1999·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·K Kwiatkowska, A Sobota
May 3, 2005·Parasitology Research·J M F DutraT M U Carvalho
Nov 26, 2010·Cell and Tissue Research·A L Maldonado-Contreras, Beth A McCormick
Dec 28, 2006·Apoptosis : an International Journal on Programmed Cell Death·J H WangB Y Chen
Dec 9, 2003·Trends in Microbiology·Bryan P Hurley, Beth A McCormick
Apr 30, 1998·Current Opinion in Cell Biology·K Ireton, P Cossart
Feb 7, 2001·Trends in Microbiology·C F LesserS I Miller
Apr 1, 1997·Trends in Microbiology·C A SchererS I Miller
Jul 1, 1997·Trends in Microbiology·K Aktories
Aug 24, 2000·Microbes and Infection·P Boquet
Aug 8, 2001·Microbes and Infection·B J Cherayil, D Antos
Aug 3, 2001·Nature Reviews. Molecular Cell Biology·P M HensonV A Fadok
May 1, 2009·Nature Cell Biology·Jason Mercer, Ari Helenius
Nov 21, 2007·Nature Reviews. Microbiology·Andrea HaragaSamuel I Miller
Dec 6, 2006·Immunology and Cell Biology·Bryan CoburnB B Finlay
Feb 24, 2001·Cellular Microbiology·W W Navarre, A Zychlinsky
Feb 24, 2001·Cellular Microbiology·B I KazmierczakJ N Engel
Feb 22, 2002·Cellular Microbiology·Juan J Martinez, Scott J Hultgren
Jun 18, 2002·Cellular Microbiology·Takanori SakaguchiHans-Christian Reinecker
Sep 1, 1999·Proceedings of the National Academy of Sciences of the United States of America·D ZhouJ E Galán
Nov 14, 1997·The Journal of Experimental Medicine·D CoxS Greenberg
May 4, 1999·The Journal of Experimental Medicine·L M ChenJ E Galán
Jun 6, 2000·The Journal of Experimental Medicine·T SuzukiC Sasakawa
Oct 12, 2000·Molecular Biology of the Cell·S DharmawardhaneG M Bokoch

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.