PMID: 11925507Apr 2, 2002Paper

Requirement of chondroitin sulfate/dermatan sulfate recognition in midkine-dependent migration of macrophages

Glycoconjugate Journal
K HayashiT Muramatsu

Abstract

Midkine (MK) is a heparin-binding growth factor that promotes cell migration, cell growth and cell survival. The promotion of migration of inflammatory cells, especially macrophages, by MK is involved in formation of a vascular abnormality, i.e. neointima formation. MK-induced migration of peritoneal exudate macrophages was inhibited by heparin, chondroitin sulfate E and dermatan sulfate, but not by chondroitin sulfate D or chondroitin 6-sulfate. Digestion of macrophages with chondroitinase ABC as well as chondroitinase B decreased the migratory activity. However, heparitinase digestion showed only slight effects. These results indicated that a chondroitin sulfate, i.e. an E-type oversulfated structure with dermatan sulfate domain, is involved in MK-induced migration of macrophages. Although a chondroitin sulfate proteoglycan, receptor-type protein tyrosine phosphatase zeta (PTP zeta), participates in MK-induced migration of neurons and osteoblasts, PTP zeta was not detected in macrophages. The MK-induced migration was inhibited by PP1, wortomanin, PD 98059 and vanadate, indicating that the downstream signaling system, which includes Src, PI3 kinase and ERK as important components, is shared with other MK signaling systems in w...Continue Reading

Citations

Oct 10, 2013·British Journal of Pharmacology·A LiedertM Amling
Oct 16, 2004·Cerebral Cortex·Payam RezaieNorbert Ulfig
Aug 10, 2006·The Journal of Clinical Endocrinology and Metabolism·Hitoshi IshimotoRobert B Jaffe
Sep 5, 2009·Clinical Chemistry and Laboratory Medicine : CCLM·Malgorzata Krzystek-KorpackaMalgorzata Matusiewicz
Sep 30, 2005·The Journal of Biological Chemistry·Shiori OhtakeOsami Habuchi
Feb 21, 2009·Nature Reviews. Neuroscience·Asya RollsMichal Schwartz
Sep 17, 2011·Advanced Functional Materials·Gregory A Hudalla, William L Murphy
May 26, 2010·Human & Experimental Toxicology·Nuray YazihanAhmet Sayal
Jul 3, 2009·Inflammatory Bowel Diseases·Malgorzata Krzystek-KorpackaMalgorzata Matusiewicz
Sep 13, 2013·British Journal of Pharmacology·A GelaA Egesten
Jan 8, 2005·American Journal of Physiology. Heart and Circulatory Physiology·Kenji HayashiTakashi Muramatsu
Oct 13, 2005·Development Genes and Evolution·Camilla EnglundRuth H Palmer
Dec 7, 2014·Journal of Cell Science·Katerina NikolovskaDaniela G Seidler

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