Requirement of clathrin heavy chain for p53-mediated transcription.

Genes & Development
Masato EnariYoichi Taya

Abstract

The p53 protein is a transcription factor that activates various genes responsible for growth arrest and/or apoptosis in response to DNA damage. Here, we report that clathrin heavy chain (CHC) binds to p53 and contributes to p53-mediated transcription. CHC is known to be a cytosolic protein that functions as a vesicle transporter. We found, however, that CHC exists not only in cytosol but also in nuclei. CHC expression enhances p53-dependent transactivation, whereas the reduction of CHC expression by RNA interference (RNAi) attenuates its transcriptional activity. Moreover, CHC binds to the p53-responsive promoter in vivo and stabilizes p53-p300 interaction to promote p53-mediated transcription. Thus, nuclear CHC is required for the transactivation of p53 target genes and plays a distinct role from clathrin-mediated endocytosis.

References

Jul 5, 1991·Science·M HollsteinC C Harris
Nov 19, 1993·Cell·W S el-DeiryB Vogelstein
Jun 19, 1997·Nature·N L LillD M Livingston
Jun 27, 1997·Cell·M L AvantaggiatiK Kelly
Feb 7, 1998·Genes & Development·J D SilicianoM B Kastan
May 28, 1998·The Journal of Biological Chemistry·J ZhuX Chen
May 26, 1999·The Journal of Pathology·C Prives, P A Hall
Feb 17, 2000·Trends in Cell Biology·O J RandoG R Crabtree
Aug 10, 2000·Neoplasia : an International Journal for Oncology Research·M Ljungman
Aug 31, 2000·Annual Review of Biochemistry·T Kirchhausen
Dec 1, 2000·Nature·B VogelsteinA J Levine
Aug 4, 2001·The American Journal of Pathology·J A BridgeS W Morris
Oct 31, 2001·Molecular Cell·Y Samuels-LevX Lu
Feb 19, 2002·Oncogene·Young R SeoMartin L Smith
Mar 23, 2002·Science·Thijn R BrummelkampReuven Agami
Jun 5, 2002·Annual Review of Biochemistry·Ivan A OlaveGerald R Crabtree
Aug 3, 2002·Nature Reviews. Cancer·Karen H Vousden, Xin Lu
Sep 6, 2002·Oncogene·Pheruza Tarapore, Kenji Fukasawa
Mar 7, 2003·Nature·Sean D Conner, Sandra L Schmid
Apr 2, 2003·Molecular Cell·Motohiro MiharaUte M Moll
Apr 30, 2003·Cell Death and Differentiation·J C BourdonD Lane
Apr 30, 2003·Cell Death and Differentiation·M Oren
Jul 9, 2003·The Journal of Biological Chemistry·Fernand GobeilSylvain Chemtob
Aug 16, 2003·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Norio ChikatsuNaoyoshi Mori
Feb 5, 2005·Trends in Biochemical Sciences·Michael J PlevinMitsuhiko Ikura
Apr 29, 2005·Nature·Stephen J RoyleLeon Lagnado

❮ Previous
Next ❯

Citations

Oct 25, 2008·Nature Reviews. Cancer·Yaron MosessonYosef Yarden
Aug 15, 2013·Nature Reviews. Molecular Cell Biology·Stephen J Royle
Jul 20, 2012·Molecular Biology of the Cell·Jessica S KelseyDaphne D Blumberg
Mar 20, 2009·Nucleic Acids Research·Ian R LoganCraig N Robson
Oct 24, 2007·Molecular and Cellular Biology·Masayoshi IizukaM Mitchell Smith
Apr 17, 2013·Molecular and Cellular Biology·Hirokazu OhataMasato Enari
Sep 23, 2008·FEBS Letters·Kohei IshiiTsuneyoshi Horigome
Apr 22, 2014·FEBS Letters·Anna ComelGiannino Del Sal
Aug 19, 2007·Seminars in Cell & Developmental Biology·Ian G Mills
Jun 23, 2007·European Journal of Cell Biology·Iwona PileckaMarta Miaczynska
Apr 18, 2009·Genes to Cells : Devoted to Molecular & Cellular Mechanisms·Jun SatoHiroshi Nojima
Jun 13, 2008·The EMBO Journal·Tomohiro YamauchiShunsuke Ishii
Sep 13, 2008·Traffic·Letizia Lanzetti, Pier Paolo Di Fiore
Mar 28, 2008·Genes to Cells : Devoted to Molecular & Cellular Mechanisms·Yoshie EndoYoichi Taya
Apr 2, 2008·EMBO Reports·Charles E Massie, Ian G Mills
Jul 15, 2011·Traffic·Anna Hupalowska, Marta Miaczynska
Apr 15, 2014·Cell Reports·Chihiro OtsuboMasato Enari
May 5, 2009·Cell·Karen H Vousden, Carol Prives
Jul 7, 2009·Molecular Oncology·Beata PyrzynskaMarta Miaczynska
Jul 28, 2009·Journal of Molecular Biology·Richard Lathe, Alyson Harris
Feb 28, 2009·Biochemical and Biophysical Research Communications·Masao SaitohKohei Miyazono
Jan 16, 2016·American Journal of Respiratory Cell and Molecular Biology·Christina MoulakakisCordula Stamme
Nov 10, 2015·Trends in Neurosciences·Michael S NahorskiC Geoffrey Woods
Feb 6, 2017·Neoplasia : an International Journal for Oncology Research·Jinichi MoriKoichi Matsuda
Dec 20, 2011·Electrophoresis·Nisha VermaSimone Schmitz-Spanke
Jan 4, 2008·Nature·Ivan N ColalucaPier Paolo Di Fiore
Jan 30, 2010·Nature·Giorgio Scita, Pier Paolo Di Fiore
Apr 25, 2019·Current Genomics·Daniel MooreFrank Emmert-Streib
Feb 3, 2012·Physiological Reviews·Sara SigismundPier Paolo Di Fiore
Apr 12, 2014·The Journal of Biological Chemistry·Monica Cubillos-RojasJose Luis Rosa
Sep 24, 2019·Journal of Biochemistry·Hiroki FujiyamaMasatoshi Fujita
Nov 6, 2014·Biomolecular Concepts·Joel A Ybe
Mar 25, 2018·Proceedings of the National Academy of Sciences of the United States of America·Sanjay AwasthiSharad S Singhal

❮ Previous
Next ❯

Related Concepts

Related Feeds

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis