Requirement of interaction of nectin-1alpha/HveC with afadin for efficient cell-cell spread of herpes simplex virus type 1

Journal of Virology
Toshiaki SakisakaYoshimi Takai

Abstract

We recently found a novel cell-cell adhesion system at cadherin-based adherens junctions (AJs), consisting at least of nectin, a Ca(2+)-independent homophilic immunoglobulin-like adhesion molecule, and afadin, an actin filament-binding protein that connects nectin to the actin cytoskeleton. Nectin is associated with cadherin through afadin and alpha-catenin. The cadherin-catenin system increases the concentration of nectin at AJs in an afadin-dependent manner. Nectin constitutes a family consisting of three members: nectin-1, -2, and -3. Nectin-1 serves as an entry and cell-cell spread mediator of herpes simplex virus type 1 (HSV-1). We studied here a role of the interaction of nectin-1alpha with afadin in entry and/or cell-cell spread of HSV-1. By the use of cadherin-deficient L cells overexpressing the full length of nectin-1alpha capable of interacting with afadin and L cells overexpressing a truncated form of nectin-1alpha incapable of interacting with afadin, we found that the interaction of nectin-1alpha with afadin increased the efficiency of cell-cell spread, but not entry, of HSV-1. This interaction did not affect the binding to nectin-1alpha of glycoprotein D, a viral component mediating entry of HSV-1 into host cells...Continue Reading

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Citations

Nov 17, 2007·Cell Host & Microbe·Joann M TaylorPatricia G Spear
Feb 21, 2003·Biochemical and Biophysical Research Communications·Masato YasumiYoshimi Takai
Jul 16, 2008·Expert Reviews in Molecular Medicine·Caroline BussmannNatalija Novak
Oct 2, 2002·Genes to Cells : Devoted to Molecular & Cellular Mechanisms·Atsunori FukuharaYoshimi Takai
Feb 1, 2003·Genes to Cells : Devoted to Molecular & Cellular Mechanisms·Tomoyuki HondaYoshimi Takai
Mar 30, 2010·Médecine sciences : M/S·Gaëlle FournierMarc Lopez
Feb 18, 2011·The Journal of Biological Chemistry·Hirotaka NaritaToshiaki Sakisaka
Sep 2, 2011·The Journal of Biological Chemistry·Souichi KuritaYoshimi Takai
Mar 12, 2011·Acta Crystallographica. Section F, Structural Biology and Crystallization Communications·Hirotaka NaritaMamoru Suzuki
Oct 17, 2001·Journal of Virology·W M Martinez, P G Spear
Feb 12, 2002·Journal of Virology·Claude KrummenacherRoselyn J Eisenberg
Jul 30, 2003·Journal of Virology·Claude KrummenacherGary H Cohen
Sep 13, 2003·Journal of Virology·Patricia G Spear, Richard Longnecker
Aug 18, 2012·Molecular Neurobiology·Giovanna De ChiaraAnna Teresa Palamara
Feb 6, 2002·The Journal of Cell Biology·Akira MizoguchiYoshimi Takai
Apr 2, 2004·Cellular Microbiology·Patricia G Spear
Nov 22, 2005·Clinical and Experimental Immunology·N Novak, W M Peng
Nov 26, 2002·The Journal of Biological Chemistry·Masanori AsadaYoshimi Takai
Feb 12, 2004·The Journal of Biological Chemistry·Wataru IkedaYoshimi Takai
Jun 24, 2003·Reviews in Medical Virology·Nancy L Cole, Charles Grose
Jun 13, 2008·Genes to Cells : Devoted to Molecular & Cellular Mechanisms·Kaori KuramitsuYoshimi Takai

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