PMID: 6159533Sep 11, 1980Paper

Requirement of nerve growth factor for development of substance P-containing sensory neurones

Nature
U OttenF Lembeck

Abstract

The protein nerve growth factor (NGF) is known to be essential for the maturation and maintenance of adrenergic neurones and for the development of sensory neurones during critical stages of embryonic life. The investigation of the physiological importance of NGF for the development of sensory neurones has been hampered so far by the lack of biochemical marker substances for these neurones. The demonstration that the undecapeptide substance P(SP) is present in sensory neurones suggests that it might be such a marker. SP is synthesized in dorsal root ganglia (DRG) and transported to the terminals of C-fibres located in the dorsal horn of the spinal cord and in the skin. Its release can be demonstrated from the central and peripheral endings of sensory nerve fibres which seem to have an important role in pain perception. We have investigated the effects of NGF and of purified anti-NGF antibodies on the content of SP in rat DRG and in their respective target organs, namely the spinal cord and the skin. The effects on sympathetic ganglia were included in order to control the effectiveness of both NGF and its antibody. We report here that NGF leads to an increase in SP in spinal ganglia, as previously shown by Kessler and Black. How...Continue Reading

References

Aug 18, 1978·Brain Research·T M JessellA C Cuello
Aug 1, 1978·Proceedings of the National Academy of Sciences of the United States of America·K SudaH Thoenen
Mar 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·J K Brunso-Bechtold, V Hamburger
Nov 17, 1977·The New England Journal of Medicine·W C MobleyE M Shooter
Jul 6, 1979·Brain Research·E TheriaultT Jessell
Aug 13, 1979·Life Sciences·R GamseF Lembeck
Jul 1, 1979·Acta Physiologica Scandinavica·A BillG Nilsson
Feb 1, 1978·Journal of Neurocytology·M SchultzbergK Pfenninger
Jun 1, 1976·Journal of Neurochemistry·K StoeckelH Thoenen
Oct 1, 1975·The Journal of Cell Biology·K Herrup, E M Shooter
Jul 1, 1968·Physiological Reviews·R Levi-Montalcini, P U Angeletti
Oct 1, 1969·Proceedings of the National Academy of Sciences of the United States of America·V Bocchini, P U Angeletti
Jul 1, 1971·Proceedings of the National Academy of Sciences of the United States of America·H ThoenenR Kettler
Mar 1, 1970·Experimental Cell Research·E L Fenton
Jan 1, 1980·Proceedings of the National Academy of Sciences of the United States of America·J A Kessler, I B Black
Apr 10, 1980·Nature·T HökfeltM Schultzberg
Jan 1, 1980·Annual Review of Neuroscience·R A NicollS E Leeman
Feb 1, 1980·Proceedings of the National Academy of Sciences of the United States of America·Y A BardeH Thoenen

❮ Previous
Next ❯

Citations

Jun 26, 1999·Microscopy Research and Technique·I Fariñas
Feb 25, 2000·Journal of Neuroscience Research·J E Adler, P D Walker
Jun 19, 1998·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·J M Frade, Y A Barde
Dec 18, 2001·The Journal of Comparative Neurology·A JosephsonC Spenger
Jul 20, 2007·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Ricarda A JoachimPetra C Arck
Jul 29, 1982·Brain Research·J P SchwartzE M Johnson
Oct 28, 1982·Brain Research·M S MillerT F Burks
Apr 18, 1995·Brain Research. Developmental Brain Research·T HirataY Kitamura
May 31, 1996·Brain Research. Developmental Brain Research·K Krieglstein, K Unsicker
Mar 13, 1989·Neuroscience Letters·C E Hulsebosch, R H Fabian
Nov 1, 1984·Neuroscience·W G Hopkins, J R Slack
Jan 1, 1988·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Y Dimberg, T Ebendal
Jan 1, 1989·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·C E Hill, M Vidovic
Dec 1, 1993·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·E Matthew

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.