Requirement of Stat3 Signaling in the Postnatal Development of Thymic Medullary Epithelial Cells

PLoS Genetics
Rumi SatohHiroshi Kawamoto

Abstract

Thymic medullary regions are formed in neonatal mice as islet-like structures, which increase in size over time and eventually fuse a few weeks after birth into a continuous structure. The development of medullary thymic epithelial cells (TEC) is dependent on NF-κB associated signaling though other signaling pathways may contribute. Here, we demonstrate that Stat3-mediated signals determine medullary TEC cellularity, architectural organization and hence the size of the medulla. Deleting Stat3 expression selectively in thymic epithelia precludes the postnatal enlargement of the medulla retaining a neonatal architecture of small separate medullary islets. In contrast, loss of Stat3 expression in cortical TEC neither affects the cellularity or organization of the epithelia. Activation of Stat3 is mainly positioned downstream of EGF-R as its ablation in TEC phenocopies the loss of Stat3 expression in these cells. These results indicate that Stat3 meditated signal via EGF-R is required for the postnatal development of thymic medullary regions.

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Citations

Feb 23, 2017·Annual Review of Immunology·Jakub Abramson, Graham Anderson
Mar 10, 2018·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Feng Zhu, Yinling Hu
Oct 21, 2018·Scandinavian Journal of Immunology·Yu GaoLili Zou
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Dec 9, 2017·Blood·Xuguang Tai
Oct 1, 2019·The Journal of Clinical Investigation·Qiumei DuNicolai Sc van Oers
May 24, 2019·Biogerontology·Mirjana Nacka-AleksićGordana Leposavić
Feb 23, 2020·Frontiers in Immunology·Hong-Xia WangYu-Rong Qiu
May 21, 2020·Frontiers in Immunology·Pratibha BhallaNicolai S C van Oers
Oct 25, 2020·Nature Reviews. Immunology·Enrico VelardiMarcel R M van den Brink
Apr 6, 2021·Frontiers in Immunology·Yu GaoMartin E Rottenberg
Jun 2, 2021·General Thoracic and Cardiovascular Surgery·Naota OkabeHiroshi Kamma
Sep 19, 2021·The Journal of Immunology : Official Journal of the American Association of Immunologists·Zhanfeng LiangYong Zhao

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Methods Mentioned

BETA
Flowcytometric
PCR
FCS
RNA seq

Software Mentioned

Axiovision4

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