PMID: 6969760Feb 1, 1981Paper

Requirement of T cells for the development of spontaneous autoimmune thyroiditis in obese strain (OS) chickens

The Journal of Immunology : Official Journal of the American Association of Immunologists
L C de CarvalhoI M Roitt

Abstract

A combination of neonatal thymectomy and intensive treatment with a highly specific turkey anti-chicken T cell serum effectively abrogates the spontaneous development of thyroiditis and thyroglobulin autoantibodies in the Obese strain chicken. Thus, in addition to a restraining influence of suppressor T cells on the disease process indicated by earlier studies, it would appear that T cells also make a positive contribution to pathogenesis.

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