PMID: 11918674Mar 29, 2002Paper

Requirement of the IFN-alpha/beta-induced CXCR3 chemokine signalling for CD8+ T cell activation

Genes to Cells : Devoted to Molecular & Cellular Mechanisms
Kouetsu OgasawaraT Taniguchi

Abstract

Activation of both CD4+ T and CD8+ T cells is triggered by the engagement of the T cell antigen receptor (TCR) with MHC/peptide complexes on antigen-presenting cells. This process also requires other molecular interactions, which transmit co-stimulatory signals to these T cells. To ensure an effective immune response, distinct T cell subsets may additionally employ unique mechanism(s) for efficient activation. We here show that mutant CD8+ T cells lacking the IFN-alpha/beta signalling components are hyporesponsive to antigen stimulation in vitro. We further show that IFN-alpha/beta-mediated signals are required for induction of the chemokines IP-10/I-TAC and their common receptor, CXCR3, and in turn provide evidence that CXCR3-mediated signals indeed function in the activation and proliferation of CD8+ T cells, particularly for the CD44low naive phenotype cells. The CXCR3 chemokine system is regulated by IFN-alpha/beta in CD8+ T cells, and it is critical for the efficient cell activation. The present study therefore reveals a novel role of the IFN-alpha/beta-CXCR3 signalling cascade in CD8+ T cell activation.

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Citations

Oct 28, 2009·Immunologic Research·Protul A ShrikantPankaj Singhal
Jun 25, 2003·Biochemical and Biophysical Research Communications·Shinya SakaguchiTadatsugu Taniguchi
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