Requirement of zinc transporter ZIP10 for epidermal development: Implication of the ZIP10-p63 axis in epithelial homeostasis

Proceedings of the National Academy of Sciences of the United States of America
Bum-Ho BinToshiyuki Fukada

Abstract

Skin tissues, in particular the epidermis, are severely affected by zinc deficiency. However, the zinc-mediated mechanisms that maintain the cells that form the epidermis have not been established. Here, we report that the zinc transporter ZIP10 is highly expressed in the outer root sheath of hair follicles and plays critical roles in epidermal development. We found that ZIP10 marked epidermal progenitor cell subsets and that ablating Zip10 caused significant epidermal hypoplasia accompanied by down-regulation of the transactivation of p63, a master regulator of epidermal progenitor cell proliferation and differentiation. Both ZIP10 and p63 are significantly increased during epidermal development, in which ZIP10-mediated zinc influx promotes p63 transactivation. Collectively, these results indicate that ZIP10 plays important roles in epidermal development via, at least in part, the ZIP10-zinc-p63 signaling axis, thereby highlighting the physiological significance of zinc regulation in the maintenance of skin epidermis.

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Citations

Feb 15, 2018·Nutrients·Youichi OgawaTatsuyoshi Kawamura
Jan 31, 2019·The Journal of Dermatology·Youichi OgawaTatsuyoshi Kawamura
Mar 5, 2019·Digestive Diseases and Sciences·Wakana OhashiToshiyuki Fukada
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Jan 10, 2019·Journal of Immunology Research·Youichi OgawaTatsuyoshi Kawamura
Aug 16, 2019·International Journal of Molecular Sciences·Mi-Gi Lee, Bum-Ho Bin
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May 30, 2020·Journal of Dermatological Science·Mi-Gi LeeBum-Ho Bin
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Oct 19, 2021·Experimental and Therapeutic Medicine·Yuan Yuan ChengFang Min Xie

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