Requirements for hydroperoxide by the cyclooxygenase and peroxidase activities of prostaglandin H synthase

Prostaglandins
R J Kulmacz, W E Lands

Abstract

Purified prostaglandin H synthase contains cyclooxygenase activity that forms the hydroperoxide, prostaglandin G, and peroxidase activity which removes hydroperoxides. Since hydroperoxides are necessary activators of cyclooxygenase activity, the paradoxical presence of two apparently opposing activities requires careful interpretation. Kinetic studies indicate that the concentration of hydroperoxide needed for full cyclooxygenase activity is much less than that which gives 50 percent effectiveness with the peroxidase. Thus, the peroxidase activity of the synthase is very ineffective in decreasing the hydroperoxide concentration below levels that still permit rapid cyclooxygenase action.

References

Jan 29, 1979·Biochimica Et Biophysica Acta·F J van der OuderaaD A van Dorp
May 25, 1977·Biochimica Et Biophysica Acta·F J Van der OuderaaD A Van Dorp
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Apr 30, 1971·Annals of the New York Academy of Sciences·W LandsW Smith
Oct 15, 1982·Biochemical Pharmacology·A M Hanel, W E Lands

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Citations

Aug 7, 1999·International Journal of Clinical & Laboratory Research·M M RicettiG Perona
Mar 9, 2013·Archives of Pharmacal Research·Allia M AbdouAshraf B Abdel-Naim
Mar 13, 2013·Archives of Pharmacal Research·Awwad A Radwan, Kamal E H elTahir
Feb 15, 1985·Analytical Biochemistry·P J MarshallW E Lands
Apr 24, 1991·Biochimica Et Biophysica Acta·W L Smith, L J Marnett
Jan 1, 1994·Molecular Aspects of Medicine·G Desoye, E Shafrir
Jan 1, 1991·Pharmacology & Therapeutics·W L SmithD L DeWitt
Jan 1, 1992·Pharmacology & Therapeutics·T E Eling, J F Curtis
Jan 1, 1989·Progress in Lipid Research·H AritaK Hanasaki
Dec 1, 1983·Prostaglandins, Leukotrienes, and Medicine·E L TolmanM E Rosenthale
Jan 1, 1984·Prostaglandins, Leukotrienes, and Medicine·W E Lands
Mar 1, 1987·Prostaglandins, Leukotrienes, and Medicine·G H RaoJ G White
Jan 1, 1985·Journal of Free Radicals in Biology & Medicine·W E Lands
Jan 1, 1992·Free Radical Biology & Medicine·G S WuN A Rao
Aug 30, 2000·Prostaglandins & Other Lipid Mediators·A Tsai, R J Kulmacz
Jun 20, 2003·Progress in Lipid Research·Richard J KulmaczAh-Lim Tsai
Nov 14, 2003·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·M A AlzoghaibiM F Graham
Oct 6, 2000·Free Radical Biology & Medicine·A M PastorinoF Ursini
Sep 28, 2000·Current Opinion in Chemical Biology·L J Marnett
Dec 22, 1999·Biochimica Et Biophysica Acta·W E Lands
Jul 1, 1987·The American Review of Respiratory Disease·W E Lands
Aug 2, 2013·Chemical & Pharmaceutical Bulletin·Fatma Abdel-Fattah RagabMona Fikry Said
Mar 3, 2007·Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan·Jin Cheng YaoLu Yong Zhang

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