PMID: 15240693Jul 9, 2004Paper

Requirements of NK cells and proinflammatory cytokines in T cell-dependent neonatal autoimmune ovarian disease triggered by immune complex

The Journal of Immunology : Official Journal of the American Association of Immunologists
Yulius Y SetiadyKenneth S K Tung

Abstract

A model of neonatal autoimmune disease has been described recently in which an epitope-specific autoantibody to murine zona pellucida 3 induces severe ovarian disease in neonatal, but not adult, mice (neonatal AOD). The autoantibody forms immune complex with endogenous ovarian zona pellucida 3, and a pathogenic CD4(+) T cell response is triggered. The basis for the predominant neonatal susceptibility has not been clarified. In this study innate immunity, including neonatal NK cells, in neonatal AOD was investigated. Neonatal spleen contained readily detectable NK1.1(+)TCRVbeta(-), but not NK1.1(+)TCRVbeta(+), cells. Ab depletion of NK1.1(+)TCRVbeta(-) cells inhibited neonatal AOD development. Moreover, in adoptive transfer of neonatal AOD, recipient disease was ameliorated when either donor or recipient NK cells were depleted. Thus, NK cells operate in both induction and effector phases of the disease. IFN-gamma was produced by neonatal NK cells in vivo, and it may be important in neonatal AOD. Indeed, ovaries with neonatal AOD expressed high levels of IFN-gamma and TNF-alpha which correlated with disease severity, and the disease was inhibited by IFN-gamma or TNF-alpha Ab. Importantly, disease was enhanced by recombinant IFN-g...Continue Reading

References

Jan 1, 1992·The Journal of Clinical Investigation·S H RhimK S Tung
Apr 1, 1982·Infection and Immunity·C Y Lu, E R Unanue
Mar 22, 1996·Science·T ForsthuberP V Lehmann
Dec 31, 1997·The Journal of Experimental Medicine·B ZhangT Tabira
May 29, 1998·European Journal of Immunology·Y MatsumotoN Tanuma
Feb 2, 1999·The Journal of Experimental Medicine·M KorsgrenO Korsgren
Jun 24, 1999·Immunology Today·B Adkins
Jan 8, 2000·Seminars in Immunology·S Amigorena, C Bonnerot
Mar 1, 2000·Proceedings of the National Academy of Sciences of the United States of America·S KimW M Yokoyama
Mar 8, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·E P BlankenhornC Teuscher
Mar 23, 2001·Nature Immunology·F D ShiH G Ljunggren
Sep 7, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·F D ShiH G Ljunggren
Oct 6, 2000·Science·J V Ravetch, L L Lanier
Oct 25, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·S MuthukkumarK E Stein
Dec 21, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·H AraseT Saito
Dec 21, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·L PricopJ E Salmon
May 4, 2001·Journal of Autoimmunity·D FairweatherN R Rose
Feb 6, 2002·The Journal of Experimental Medicine·Franca GerosaGiorgio Trinchieri
Feb 6, 2002·The Journal of Experimental Medicine·Diego PiccioliNicholas M Valiante
Feb 23, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Danita H SchuurhuisFerry Ossendorp
Apr 3, 2002·Nature Medicine·Siri Atma W GreeleyHooman Noorchashm
Apr 27, 2002·Scandinavian Journal of Immunology·M FlodströmH-G Ljunggren
Jun 19, 2002·The Journal of Experimental Medicine·Alexis M Kalergis, Jeffrey V Ravetch
Jan 18, 2003·Science·Chandrashekhar Pasare, Ruslan Medzhitov
Apr 23, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Yulius Y SetiadyKenneth S K Tung
Aug 21, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Robbie B MailliardPawel Kalinski
Jan 7, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Amanda M JamiesonDavid H Raulet
Jan 7, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Aleksandar DakicLi Wu

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Citations

May 1, 2005·Expert Review of Clinical Immunology·Simon SkurkovichJeanne Kelly
Nov 20, 2016·Clinical and Experimental Pharmacology & Physiology·Yupan ZhangYanfang Jiang
Dec 29, 2005·Journal of Clinical Immunology·Kouetsu Ogasawara, Lewis L Lanier
Jun 5, 2016·The Journal of Immunology : Official Journal of the American Association of Immunologists·Jessica HarakalKenneth S Tung
Aug 30, 2005·Annals of the New York Academy of Sciences·Simon Skurkovich, Boris Skurkovich
Aug 21, 2013·The Journal of Immunology : Official Journal of the American Association of Immunologists·Claudia RivalKenneth Tung
Jan 20, 2012·The Korean Journal of Hematology·Raja Rajalingam
Sep 1, 2012·American Journal of Reproductive Immunology : AJRI·Xiaolin MaFuchun Zhang
Nov 2, 2016·The Journal of Immunology : Official Journal of the American Association of Immunologists·Jean WuYahuan Lou

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