PMID: 8980224Dec 27, 1996Paper

Requisite role of angiopoietin-1, a ligand for the TIE2 receptor, during embryonic angiogenesis

Cell
Chitra SuriG D Yancopoulos

Abstract

Vascular endothelial growth factor (VEGF), which acts via members of a family of endothelial-specific receptor tyrosine kinases, is the only factor that has been shown definitively to play a role in the formation of the embryonic vasculature. Only one other family of receptor tyrosine kinases, comprising TIE1 and TIE2, is largely endothelial cell specific. We have recently cloned a ligand for TIE2, termed Angiopoietin-1. Here we show that mice engineered to lack Angiopoietin-1 display angiogenic deficits reminiscent of those previously seen in mice lacking TIE2, demonstrating that Angiopoietin-1 is a primary physiologic ligand for TIE2 and that it has critical in vivo angiogenic actions that are distinct from VEGF and that are not reflected in the classic in vitro assays used to characterize VEGF. Angiopoietin-1 seems to play a crucial role in mediating reciprocal interactions between the endothelium and surrounding matrix and mesenchyme.

References

Nov 23, 1995·Nature·D Meyer, C Birchmeier
May 1, 1995·The Journal of Cell Biology·T Mustonen, K Alitalo
Mar 27, 1995·Annals of the New York Academy of Sciences·N FerraraG R Thomas
Aug 15, 1995·Proceedings of the National Academy of Sciences of the United States of America·C J Drake, C D Little
May 1, 1995·Developmental Dynamics : an Official Publication of the American Association of Anatomists·D J DumontM L Breitman
Oct 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·T N SatoK L Audus
Jan 1, 1995·Breast Cancer Research and Treatment·N Ferrara
May 14, 1996·Proceedings of the National Academy of Sciences of the United States of America·R KramerL E Theill
Sep 5, 1996·Nature·P CarmelietD Collen

❮ Previous
Next ❯

Citations

May 29, 1998·Developmental Dynamics : an Official Publication of the American Association of Anatomists·J E FlemingA I Caplan
May 29, 1998·Developmental Dynamics : an Official Publication of the American Association of Anatomists·M S LyonsK G Peters
Feb 19, 2000·Developmental Dynamics : an Official Publication of the American Association of Anatomists·A L AkesonJ M Greenberg
Dec 17, 1997·International Journal of Cancer. Journal International Du Cancer·T A OlsonS Ramakrishnan
Oct 22, 1998·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·L Robb, A G Elefanty
Nov 21, 2000·Developmental Dynamics : an Official Publication of the American Association of Anatomists·B D Abbott, A R Buckalew
Feb 13, 2001·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Y M LeeK W Kim
Jul 27, 2000·Journal of Cellular Physiology·S F HackettP A Campochiaro
Jul 27, 2000·Journal of Cellular Physiology·P A Campochiaro
Sep 14, 2000·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·B L Roman, B M Weinstein
Jun 17, 1998·Arthritis and Rheumatism·A E Koch
Sep 5, 2002·The Anatomical Record·David H Bernanke, J Matthew Velkey
Oct 17, 2002·The Anatomical Record·George E DavisAnil Mavila
Aug 31, 2002·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Valentin G DjonovPeter H Burri
Jul 18, 2001·Developmental Dynamics : an Official Publication of the American Association of Anatomists·R J TomanekP R Suvarna
Aug 14, 2001·Developmental Dynamics : an Official Publication of the American Association of Anatomists·V N PhamB M Weinstein
Aug 17, 2001·Developmental Dynamics : an Official Publication of the American Association of Anatomists·M Kolatsi-JoannouA S Woolf
May 7, 2002·International Journal of Cancer. Journal International Du Cancer·Kazuo ShirakawaHiro Wakasugi
Jul 13, 2002·International Journal of Cancer. Journal International Du Cancer·Kazuo ShirakawaFumio Konishi
Sep 5, 2002·International Journal of Cancer. Journal International Du Cancer·Alfonso CalvoJeffrey E Green
Mar 29, 2002·Microscopy Research and Technique·Kathleen M Caron, Oliver Smithies
Aug 28, 2003·Microsurgery·Howard JungMaria Siemionow
Aug 30, 2008·Science in China. Series C, Life Sciences·K ZhangL Bai
Nov 28, 2001·International Journal of Hematology·T Suda, N Takakura
Aug 21, 2007·Molecular Diagnosis & Therapy·Kenta Nakamura, Stanley G Rockson
May 21, 2005·Cellular and Molecular Life Sciences : CMLS·A A TimurQ Wang
Nov 5, 2004·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Paul N MorrisNicholas P J Brindle
Apr 2, 2009·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Masahiro Murakami, Michael Simons
Aug 9, 2011·Annals of Hematology·Chaiwat JiraritthamrongSurapol Issaragrisil
Jan 15, 2009·Acta Neuropathologica·Heike Beck, Karl H Plate
Oct 7, 2008·Histochemistry and Cell Biology·Hiroshi Shimoda
May 9, 2009·Histochemistry and Cell Biology·Elena BogdanovicDaniel J Dumont
Feb 17, 2005·Cell and Tissue Research·Joanna KosackaKatharina Spanel-Borowski
Jul 24, 2008·Cell and Tissue Research·Giorgia Jurisic, Michael Detmar
Aug 30, 2008·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Jiangzi YuanJiaqi Qian
Aug 13, 2008·Journal of Orthopaedic Science : Official Journal of the Japanese Orthopaedic Association·Kenichi NakamuraKatsuro Tomita
Apr 20, 2006·International Journal of Clinical Oncology·Shigeru KandaHiroshi Kanetake
Oct 24, 2008·International Journal of Clinical Oncology·Jiro Fujimoto
Oct 20, 2006·Angiogenesis·Pamela F Jones, Brian D Sleeman
Feb 27, 2007·Angiogenesis·Marcus Fruttiger

❮ Previous
Next ❯

Related Concepts

Related Feeds

Arterial-Venous in Development & Disease

Arterial-venous development may play a crucial role in cardiovascular diseases. Here is the latest research.

Cell eTOC

Cell is a scientific journal publishing research across a broad range of disciplines within the life sciences field. Discover the latest research from Cell here.