Resampling the pool of genotypic possibilities: an adaptive function of sexual reproduction.

BMC Ecology and Evolution
Donal A. Hickey, G. B. Golding

Abstract

Natural populations harbor significant levels of genetic variability. Because of this standing genetic variation, the number of possible genotypic combinations is many orders of magnitude greater than the population size. This means that any given population contains only a tiny fraction of all possible genotypic combinations. We show that recombination allows a finite population to resample the genotype pool, i.e., the universe of all possible genotypic combinations. Recombination, in combination with natural selection, enables an evolving sexual population to replace existing genotypes with new, higher-fitness genotypic combinations that did not previously exist in the population. This process allows the sexual population to gradually increase its fitness far beyond the range of fitnesses in the initial population. In contrast to this, an asexual population is limited to selection among existing lower fitness genotypes. The results provide an explanation for the ubiquity of sexual reproduction in evolving natural populations, especially when natural selection is acting on the standing genetic variation.

References

Oct 15, 1985·Experientia·S C Stearns
Jan 5, 2002·Evolution; International Journal of Organic Evolution·S P Otto, N H Barton
Jul 22, 2006·Biochemical Society Transactions·S P Otto, A C Gerstein
Nov 17, 2007·Trends in Ecology & Evolution·Rowan D H Barrett, Dolph Schluter
Jan 13, 2009·Nature Genetics·Henrique TeotónioAnthony D Long
May 16, 2009·The American Naturalist·Sarah P Otto
Sep 17, 2010·Nature·Molly K BurkeAnthony D Long
Jul 1, 2014·Proceedings of the National Academy of Sciences of the United States of America·Erick ChastainUmesh Vazirani
Feb 26, 2016·Nature·Michael J McDonaldMichael M Desai
May 20, 2017·Journal of Theoretical Biology·Omer EdhanDana Sherill-Rofe
Oct 27, 2017·Molecular Biology and Evolution·Katya Kosheleva, Michael M Desai
Jan 23, 2018·Journal of Theoretical Biology·Donal A Hickey, G Brian Golding
Aug 23, 2019·Genome Génome / Conseil National De Recherches Canada·Donal A Hickey, G Brian Golding
Jul 1, 2020·Nature Reviews. Genetics·Neda BarghiChristian Schlötterer
Nov 24, 2020·Biology Direct·Liudmyla VasylenkoAdi Livnat

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