Rescue chemotherapy for patients with resistant or relapsed endemic Burkitt's lymphoma

Transactions of the Royal Society of Tropical Medicine and Hygiene
P B HesselingR Broadhead

Abstract

Patients with endemic Burkitt's lymphoma who failed primary treatment with the Malawi 2002 or 2003 Burkitt's lymphoma treatment protocols, consisting of high frequency cyclophosphamide 40 mg/kg and intrathecal methotrexate, were offered rescue chemotherapy. Twenty-eight patients (14 boys and 14 girls; age range 3-13 years) with resistant disease (n=8) or relapse (n=20) presented to the Queen Elizabeth Central Hospital, Blantyre, Malawi. Treatment consisted of cyclophosphamide 60 mg/kg and vincristine 1.5 mg/m(2) i.v. on Days 1, 8 and 15, plus intrathecal methotrexate on the same days in those patients treated for a relapse. The majority of patients (81%) had St Jude stage III or IV disease. Twenty patients (71%) achieved a complete clinical remission. Day 8 treatment was delayed in eight children and Day 15 treatment in five patients, both for a median of 7 days, mainly due to neutropenia. Ten patients relapsed after 42-311 days (median 105 days). Ten patients (36%) remained in remission for 353-712 days (median 487 days). Patients whose first relapse occurred after 6 months as well as those with limited disease had the best outcome. This simple 15-day chemotherapy schedule salvaged 36% of patients and significantly increased t...Continue Reading

References

Apr 15, 1976·International Journal of Cancer. Journal International Du Cancer·C L OlwenyI T Magrath
Oct 1, 1977·Cancer·F K NkrumahR J Biggar
Aug 26, 1998·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·P N PostJ W Coebergh
Nov 5, 2003·Medical and Pediatric Oncology·Peter B HesselingGlynn Wessels

❮ Previous
Next ❯

Citations

Jul 31, 2013·Nature Reviews. Clinical Oncology·Trijn IsraëlsElizabeth M Molyneux
Jul 28, 2011·Current Oncology Reports·Juan Carlos Ramos, Izidore S Lossos
Nov 26, 2015·Pediatric Hematology and Oncology·P B HesselingP Wharin
Nov 29, 2016·British Journal of Haematology·Elizabeth MolyneuxSimon Bailey
Jul 24, 2015·International Journal of Palliative Nursing·Mona TamannaiPeter B Hesseling
Jul 1, 2010·Pediatric Blood & Cancer·Peter HesselingGeorge Tata
Mar 4, 2011·Pediatric Blood & Cancer·S MarjerrisonP Hesseling
Nov 30, 2012·Pediatric Blood & Cancer·Peter HesselingUNKNOWN Pediatric Oncology in Developing Countries
Feb 18, 2021·Journal of Tropical Pediatrics·Peter B Hesseling PhDFrancine Kouya Md
Mar 16, 2021·Pediatric Blood & Cancer·Glenn Mbah AfungchwiPeter B Hesseling
Dec 7, 2021·British Journal of Haematology·Maria Luisa MoletiRobin Foà
Feb 16, 2012·Lancet·Elizabeth M MolyneuxSimon Bailey

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.