Rescue high frequency oscillatory ventilation for preterm infants: neurodevelopmental outcome and its prediction

Biology of the Neonate
P Y CheungC M Robertson

Abstract

The role of rescue high-frequency oscillatory ventilation (HFO) in treating very-low-birth-weight neonates with severe respiratory failure in relation to neurodevelopmental outcome has not been evaluated. We performed a retrospective cohort study on 21 patients (out of 52 consecutively admitted preterm neonates with gestational age < or = 30 weeks and birth weight < or = 1.250 g; mortality rate 60%) rescued with HFO between October 1988 and August 1993. Neurodevelopment, including Bayley Scales in Infant Development, was assessed at 12-61 (mean 28.5) months adjusted age. Thirteen normal (scores better than 2 SD below mean, and no sensory or motor disability) (62%) and neurodevelopmentally disabled children (38%) survived more than 1 year for developmental assessment. The mental and performance developmental indices were 94 (78-117) and 89 (68-110), and 63 (49-102) and 49 for the 13 normal and 8 disabled children, respectively (both p < 0.05). The incidence of bronchopulmonary dysplasia, intraventricular hemorrhage (IVH; grade 3 or 4), growth retardation, developmental scores and disabilities of these 21 HFO survivors were not significantly different from that of a birth-weight- and gestational-age-matched comparison group. Whil...Continue Reading

Citations

Mar 2, 2002·Early Human Development·Gabriel DimitriouMargaret Morton
Mar 31, 2007·Clinics in Perinatology·Anne Greenough, Steven M Donn
Jun 27, 2006·Paediatric Respiratory Reviews·Anne Greenough
Nov 10, 2005·Early Human Development·Anne Greenough, Atul Sharma

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