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Rescue of glaucoma-causing mutant myocilin thermal stability by chemical chaperones

ACS Chemical Biology

Mar 26, 2010

J Nicole BurnsRaquel L Lieberman

Abstract

Mutations in myocilin cause an inherited form of open angle glaucoma, a prevalent neurodegenerative disorder associated with increased intraocular pressure. Myocilin forms part of the trabecular meshwork extracellular matrix presumed to regulate intraocular pressure. Missense mutations,...read more

Mentioned in this Paper

Alkalescens-Dispar Group
Methylamines
Aggregation
Extracellular Matrix
Trimethyloxamine
Mutant Proteins
Pancortin 4 protein, mouse
Eye Proteins
Process of Secretion
Olfactomedin
19
Paper Details
References
  • References48
  • Citations27
12345
  • References48
  • Citations27
123

Rescue of glaucoma-causing mutant myocilin thermal stability by chemical chaperones

ACS Chemical Biology

Mar 26, 2010

J Nicole BurnsRaquel L Lieberman

PMID: 20334347

DOI: 10.1021/cb900282e

Abstract

Mutations in myocilin cause an inherited form of open angle glaucoma, a prevalent neurodegenerative disorder associated with increased intraocular pressure. Myocilin forms part of the trabecular meshwork extracellular matrix presumed to regulate intraocular pressure. Missense mutations,...read more

Mentioned in this Paper

Alkalescens-Dispar Group
Methylamines
Aggregation
Extracellular Matrix
Trimethyloxamine
Mutant Proteins
Pancortin 4 protein, mouse
Eye Proteins
Process of Secretion
Olfactomedin
19

Related Papers

Paper Details
References
  • References48
  • Citations27
12345
  • References48
  • Citations27
123
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