Rescue therapy with intravitreal aflibercept for choroidal neovascularization secondary to choroidal osteoma non-responder to intravitreal bevacizumab and ranibizumab

International Ophthalmology
Andrea SaittaCesare Mariotti

Abstract

To investigate the effect of aflibercept in a rare case of choroidal neovascularization (CNV) secondary to choroidal osteoma (CO) and refractory to ranibizumab and bevacizumab. A 45-year-old male with CO-related CNV in his left eye received prior two intravitreal 1.25 mg bevacizumab injections and three intravitreal 0.5 mg ranibizumab injections without visual and anatomic improvement. Best-corrected visual acuity assessment, ophthalmic examination, fundus photography, and optical coherence tomography (OCT) were performed. Switching to intravitreal injection of 2.0 mg aflibercept was performed. After three loading doses of intravitreal aflibercept, visual acuity of the left eye improved from 20/50 to 20/32. Resolution of the persistent subfoveal fluid and reduction of retinal hemorrhage were confirmed according to ophthalmoscopy and OCT findings. No serious adverse events were observed. The treatment effect persisted during a 10-month follow-up period. In choroidal osteoma, switching to intravitreal aflibercept injection may be an effective therapeutic option for treatment of CNV refractory to ranibizumab and bevacizumab.

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Citations

Oct 4, 2017·Asia-Pacific Journal of Ophthalmology·Sumit Randhir SinghJay Chhablani
Jan 26, 2017·The British Journal of Ophthalmology·Imoro Zeba BraimahUNKNOWN ‘Ziv-aflibercept study group’
May 26, 2017·Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft·A SchuhK Eibl-Lindner
Apr 24, 2018·BioMed Research International·Xinyuan Zhang, Timothy Y Y Lai
Feb 8, 2019·Current Pharmaceutical Design·Andrzej Grzybowski, Piotr Kanclerz
Aug 24, 2021·International Ophthalmology·Pukhraj RishiUNKNOWN Sankara Nethralaya Vitreoretinal Study Group

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