Abstract
All renal allograft recipients (n = 32) in Sweden and Norway who were converted from cyclosporin (CyA)-based immunosuppression to FK 506 (tacrolimus) between October 1992 and June 1995 were analyzed retrospectively. The reasons for conversion were acute refractory rejection (n = 21), chronic rejection (n = 4), and suspected CyA toxicity (n = 6); one patient was converted for psychological reasons. The mean time from transplantation to conversion was 29 (range 1-243) weeks and there was a mean follow-up of 46 (2-143) weeks. Overall graft survival was 59%, with graft survival 52% in patients converted because of acute rejection, 50% in patients converted because of chronic rejection, and 83% in patients converted because of CyA toxicity. There was no significant correlation between preconversion serum creatinine and outcome. Seventy-two percent of the patients had significant side effects during FK 506 treatment, the most frequent ones being neurological and gastrointestinal symptoms. These improved after dose reduction. Two patients became overimmunosuppressed and developed lymphoma. One patient died of the primary kidney disease, hemolytic uraemic syndrome. We conclude that FK 506 therapy is able to salvage kidneys with acute r...Continue Reading
References
Feb 1, 1992·Transplantation·P S AlmondD L Dunn
Mar 27, 1994·Transplantation·M L JordanJ J Fung
Oct 27, 1994·The New England Journal of Medicine·UNKNOWN U.S. Multicenter FK506 Liver Study Group
Dec 1, 1993·Journal of the American Society of Nephrology : JASN·C Y LuM A Vazquez
Aug 1, 1993·Kidney International·K SolezP F Halloran
Citations
Jul 2, 2003·Microsurgery·Ramsay A EllisDaniel A Hunter
Dec 26, 2001·Transplantation Proceedings·C BlumeB Grabensee
Aug 15, 2002·Transplantation Proceedings·K BuddeH-H Neumayer
Jun 24, 1998·Transplantation Proceedings·K BuddeH H Neumayer
Jun 24, 1998·Transplantation Proceedings·V KliemR Brunkhorst
Jun 24, 1998·Transplantation Proceedings·M L JordanT E Starzl
Sep 2, 1998·Transplantation Proceedings·P A Keown, D R Primmett
Sep 2, 1998·Transplantation Proceedings·K BuddeH H Neumayer
Jun 18, 1999·Transplantation Proceedings·P A Keown
Nov 27, 1999·Transplantation Proceedings·V KliemR Brunkhorst
Nov 27, 1999·Transplantation Proceedings·M L JordanT E Starzl
Nov 25, 2000·The British Journal of Surgery·G R BicknellM L Nicholson
Dec 10, 2003·Plastic and Reconstructive Surgery·Roberta K YangSusan E Mackinnon
Jan 17, 2003·Paediatric Drugs·Dominique DebrayChristophe Chardot
Dec 23, 1999·Transplant Immunology·Z QiH Ekberg
Oct 16, 2015·Toxicology Mechanisms and Methods·Hanen FerjaniHassen Bacha
Sep 20, 2018·Biotechnology and Bioengineering·Pratima LabrooJayant Agarwal
May 22, 2021·Experimental and Clinical Transplantation : Official Journal of the Middle East Society for Organ Transplantation·Ozlem Tugce Cilingir-KayaSemra Karsidag