PMID: 29483923DOI: 10.1155/2018/5289859Feb 28, 2018Paper
Research Advances in the Correlation between Peroxisome Proliferator-Activated Receptor-γ and Digestive Cancers
PPAR Research
Shuqi Xu, Xuanfu Xu
Abstract
Peroxisome proliferator-activated receptor-γ (PPARγ) is a class of ligand-activated nuclear transcription factors, which is a member of type II nuclear receptor superfamily. Previous studies demonstrate that PPARγ is expressed in a variety of tumor tissues and is closely associated with the proliferation and prognosis of digestive system tumors by its roles in mediation of cell differentiation, induction of cell apoptosis, and inhibition of cell proliferation.
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Apoptosis
Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis