Research Advances in the Mechanisms of Hyperuricemia-Induced Renal Injury.

BioMed Research International
Hong-Yong SuHua-Feng Liu

Abstract

Uric acid is the end product of purine metabolism in humans, and its excessive accumulation leads to hyperuricemia and urate crystal deposition in tissues including joints and kidneys. Hyperuricemia is considered an independent risk factor for cardiovascular and renal diseases. Although the symptoms of hyperuricemia-induced renal injury have long been known, the pathophysiological molecular mechanisms are not completely understood. In this review, we focus on the research advances in the mechanisms of hyperuricemia-caused renal injury, primarily on oxidative stress, endothelial dysfunction, renal fibrosis, and inflammation. Furthermore, we discuss the progress in hyperuricemia management.

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Citations

Jan 4, 2021·International Urology and Nephrology·Yan ZhangDing-Wei Yang
Dec 11, 2020·Scientifica·Nour Elhouda DaoudiMohamed Bnouham
Mar 7, 2021·Nutrients·Simonetta GenovesiGianfranco Parati
Apr 16, 2021·Oxidative Medicine and Cellular Longevity·Ning LiuWenjie Lu
Aug 6, 2021·International Immunopharmacology·Lan LiYanrong Lu
Sep 23, 2021·Journal of Agricultural and Food Chemistry·Xiaoqing LiChao Zhao

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